Schutte Debra L, Mukhopadhyay N, Holwerda Teri, Sluka Kathleen, Rakel Barbara, Govil Manika
Res Gerontol Nurs. 2020 Apr 13:1-12. doi: 10.3928/19404921-20200312-01.
The purpose of this study was to examine genetic variability and knee pain in persons with osteoarthritis (OA). Seventy-five participants with medial compartment knee OA were recruited from a large Midwestern tertiary care center. Participants exhibited a mean age of 56.3 years; females comprised 61% of the sample. Measures of pain included subjective pain intensity at rest and with movement, cutaneous mechanical sensation and pain testing, heat pain threshold, and pressure pain threshold. Seventy-four participants were genotyped for 25 genetic variants across 15 candidate genes for central or peripheral pain pathways. Analysis suggests a role for four genes (EDNRA, COMT, BDRKB1, and IL1B) in several components of pain in persons with knee OA. The results from this study will help guide the development and evaluation of tailored strategies to decrease pain, improve function, and prevent the development of new chronic pain syndromes in older adults experiencing OA. [Research in Gerontological Nursing, xx(x), xx-xx.].
本研究的目的是检查骨关节炎（OA）患者的基因变异性和膝关节疼痛情况。从一家大型中西部三级护理中心招募了75名患有内侧间室膝关节OA的参与者。参与者的平均年龄为56.3岁；女性占样本的61%。疼痛测量指标包括静息和运动时的主观疼痛强度、皮肤机械感觉和疼痛测试、热痛阈值以及压痛阈值。对74名参与者进行了基因分型，检测了15个与中枢或外周疼痛通路相关的候选基因中的25个基因变体。分析表明，四个基因（内皮素受体A基因（EDNRA）、儿茶酚-O-甲基转移酶基因（COMT）、缓激肽B1受体基因（BDRKB1）和白细胞介素1β基因（IL1B））在膝关节OA患者疼痛的几个组成部分中发挥作用。本研究结果将有助于指导制定和评估针对性策略，以减轻疼痛、改善功能，并预防患有OA的老年人出现新的慢性疼痛综合征。[《老年护理研究》，xx(x)，xx - xx。]
