Steinheider G, Schaefer A, Westendorf J, Marquardt H
Department of Toxicology, Hamburg University Medical School, Federal Republic of Germany.
Cell Biol Toxicol. 1988 Mar;4(1):123-33. doi: 10.1007/BF00141291.
The oligosaccharide-anthracyclines, aclacinomycin A, marcellomycin and musettamycin, are potent inducers of erythroid differentiation in hemopoietic cells lines of rodent and human origin. The present studies revealed that pyrromycin, a closely related monosaccharide-anthracycline, induced erythroid differentiation in Friend leukemia cells and in the human leukemia cell line K 562. Pyrromycin, marcellomycin and musettamycin, which possess an identical aglycone structure containing a Cl-hydroxyl group, exhibited relatively low optimal inductive concentrations. In contrast, the optimal inductive concentration of aclacinomycin A, which lacks the Cl-hydroxyl group, was markedly higher, i.e., the differentiation inducing capacity was lower. It should be noted, however, that the yield of differentiated cells following treatment with the monosaccharide-anthracycline pyrromycin was distinctly lower than that after treatment with the oligo-saccharide-anthracyclines, aclacinomycin A, marcellomycin or musettamycin. Thus, our data indicate that the efficacy of anthracyclines to induce erythroid differentiation is related to a) the presence of a Cl-hydroxyl group in the aglycone and b) the presence of an oligosaccharide side chain.
寡糖蒽环类抗生素、阿克拉霉素A、马塞洛霉素和穆塞他霉素是啮齿动物和人类造血细胞系中红细胞分化的有效诱导剂。目前的研究表明，吡咯霉素，一种密切相关的单糖蒽环类抗生素，可诱导弗氏白血病细胞和人白血病细胞系K562中的红细胞分化。吡咯霉素、马塞洛霉素和穆塞他霉素具有相同的苷元结构，含有一个Cl-羟基，表现出相对较低的最佳诱导浓度。相比之下，缺乏Cl-羟基的阿克拉霉素A的最佳诱导浓度明显更高，即分化诱导能力较低。然而，应该注意的是，用单糖蒽环类抗生素吡咯霉素处理后分化细胞的产量明显低于用寡糖蒽环类抗生素、阿克拉霉素A、马塞洛霉素或穆塞他霉素处理后的产量。因此，我们的数据表明蒽环类抗生素诱导红细胞分化的功效与a）苷元中Cl-羟基的存在和b）寡糖侧链的存在有关。
