University of Michigan, School of Nursing and Adult Bone Marrow Transplant Unit, Ann Arbor, Michigan.
Grace A. Kanzawa-Lee, PhD, RN, is an adult bone marrow transplant registered nurse, nursing PhD, Hillman Scholar, and American Cancer Society Doctoral Scholarship recipient at the University of Michigan. She has conducted 7 years of research and authored 14 publications on chemotherapy-induced peripheral neuropathy and neuropathic pain. Her main research interest is behavioral/nonpharmacological interventions.
J Infus Nurs. 2020 May/Jun;43(3):155-166. doi: 10.1097/NAN.0000000000000368.
Chemotherapy-induced peripheral neuropathy (CIPN) is an unsolved and potentially life-compromising problem for most patients receiving neurotoxic chemotherapy. It manifests with numbness, tingling, and possibly neuropathic pain and motor and autonomic symptoms. This review aims to provide an evidence synthesis that prepares nurses to comprehensively assess, provide supportive care for, and critically evaluate the literature on CIPN. The prevalence, significance, characteristics, mechanisms, and risk factors of CIPN will be discussed, as well as nursing-relevant evidence on the assessment, prevention, and management of CIPN. The importance of critical literature evaluation before clinical implementation to reduce physical and financial harms to patients will also be highlighted.
化疗引起的周围神经病（CIPN）是大多数接受神经毒性化疗的患者尚未解决且可能危及生命的问题。其表现为麻木、刺痛，可能还有神经病理性疼痛以及运动和自主症状。本篇综述旨在提供证据综合，使护士能够全面评估、提供支持性护理，并批判性评估 CIPN 的文献。本文将讨论 CIPN 的患病率、意义、特征、机制和危险因素，以及护理相关的 CIPN 评估、预防和管理方面的证据。在临床实施前进行关键文献评估以减少对患者的身体和经济伤害的重要性也将得到强调。
