School of Nursing, Jilin University, 965 Xinjiang Street, Changchun, 130021, Jilin, China.
Department of Nursing, The First Bethune Hospital of Jilin University, Changchun, 130021, Jilin, China.
J Cancer Surviv. 2023 Apr;17(2):318-331. doi: 10.1007/s11764-022-01182-3. Epub 2022 Feb 11.
Summarize and critically evaluate the existing studies to determine the effects of exercise on chemotherapy-induced peripheral neuropathy in cancer patients.
We searched PubMed, Scopus, Web of Science, and Cochrane Library databases for randomized controlled trials reporting exercise intervention in cancer patients with chemotherapy-induced peripheral neuropathy. The outcomes of interest included chemotherapy-induced peripheral neuropathy symptoms, physical function (balance control, muscle strength, and functional status), and quality of life. The Cochrane Collaboration's tool was employed to assess the risk of bias.
The search identified 1309 studies, 16 of which eligible. Our meta-analysis revealed that exercise intervention significantly improved the quality of life (SMD = 0.83, 95% CI = 0.58 to 1.08, I = 0%, P < 0.00001) and relieved neuropathic pain (MD = - 4.93, 95% CI = - 5.60 to - 4.26, I = 0%, P < 0.00001). The muscular strength of the upper (SMD = 1.10, 95% CI = 0.68 to 1.51, I = 25%, P < 0.00001) and the lower limbs (SMD = 0.84, 95% CI = 0.42 to 1.26, I = 36%, P < 0.00001) increased and balance performance (SMD = 1.05, 95% CI = 0.62 to1.48, I = 0%, P < 0.00001) was better in the exercise group than in the group with usual care. However, no evidence was found that exercise intervention could improve CIPN symptoms.
The results of this study showed that combined exercise could be an effective option for improving quality of life, physical function (balance control and muscle strength), and neuropathic pain in cancer patients with chemotherapy-induced peripheral neuropathy. Further exploration of appropriate exercise prescriptions is needed to improve other outcomes.
Specific and appropriate exercise intervention for cancer patients with chemotherapy-induced peripheral neuropathy should be recommended because these interventions can improve their quality of life and physical function.
总结和评估现有研究，以确定运动对癌症患者化疗引起的周围神经病的影响。
我们检索了 PubMed、Scopus、Web of Science 和 Cochrane Library 数据库中关于癌症患者化疗引起的周围神经病进行运动干预的随机对照试验。主要结局指标包括化疗引起的周围神经病症状、身体功能（平衡控制、肌肉力量和功能状态）和生活质量。采用 Cochrane 协作组工具评估偏倚风险。
搜索共确定了 1309 项研究，其中 16 项符合纳入标准。我们的荟萃分析显示，运动干预显著改善了生活质量（SMD=0.83，95%CI=0.58 至 1.08，I=0%，P<0.00001）和缓解神经病理性疼痛（MD=-4.93，95%CI=-5.60 至-4.26，I=0%，P<0.00001）。上肢肌肉力量（SMD=1.10，95%CI=0.68 至 1.51，I=25%，P<0.00001）和下肢肌肉力量（SMD=0.84，95%CI=0.42 至 1.26，I=36%，P<0.00001）增加，平衡能力（SMD=1.05，95%CI=0.62 至 1.48，I=0%，P<0.00001）提高，运动组比常规护理组的神经病理性疼痛更好。然而，没有证据表明运动干预可以改善 CIPN 症状。
本研究结果表明，联合运动可能是改善癌症患者化疗引起的周围神经病生活质量、身体功能（平衡控制和肌肉力量）和神经病理性疼痛的有效选择。需要进一步探索适当的运动处方，以改善其他结局。
对于癌症幸存者来说，应推荐针对癌症患者化疗引起的周围神经病的特定和适当的运动干预，因为这些干预措施可以提高他们的生活质量和身体功能。
