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老挝特应性皮炎患儿斑贴试验结果。

Patch test results in paediatric patients with atopic dermatitis in Laos.

机构信息

Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Vientiane, Laos.

Churchill Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom.

出版信息

PLoS One. 2020 Apr 14;15(4):e0231455. doi: 10.1371/journal.pone.0231455. eCollection 2020.

Abstract

BACKGROUND

Dermatological services in Laos, South East Asia are limited mainly to the capital and patch testing is currently not available, so no data exists regarding the common cutaneous allergens in this population.

OBJECTIVES

The aim of this study was to document common allergens in paediatric patients with atopic dermatitis attending the allergy clinic in the capital, Vientiane.

PATIENTS/MATERIALS/METHODS: Fifty paediatric patients with atopic dermatitis were patch tested using TRUE Test® panels 1 to 3 (35 allergens). Readings were taken at Days 2 and 4.

RESULTS

Twenty-six positive patch tests were recorded on Day 4 in 15 children (30%). The most common allergens were: gold (18%), nickel (10%), formaldehyde (6%) and p-Phenylenediamine (6%). Other positive allergens were potassium dichromate (2%), cobalt dichloride (2%), Bronopol (2%), paraben mix (2%), fragrance mix 1 (2%) and neomycin (2%). The majority of the patients with positive reactions were female.

CONCLUSIONS

This study represents the first documented patch test results in the Lao population. It is hoped that these findings will help clinicians to advise the families of children with atopic dermatitis on common allergens to avoid and inform future work on contact dermatitis in this population.

摘要

背景

东南亚老挝的皮肤科服务主要集中在首都,目前还不能进行斑贴试验,因此,关于该人群常见的皮肤过敏原,尚无数据。

目的

本研究旨在记录首都万象过敏诊所就诊的特应性皮炎儿科患者的常见过敏原。

患者/材料/方法:对 50 名特应性皮炎患儿进行 TRUE Test® 第 1 至 3 板(35 种过敏原)斑贴试验。在第 2 天和第 4 天进行读数。

结果

在 15 名儿童(30%)的第 4 天记录了 26 次阳性斑贴试验。最常见的过敏原是:金(18%)、镍(10%)、甲醛(6%)和对苯二胺(6%)。其他阳性过敏原还有重铬酸钾(2%)、氯化钴(2%)、溴硝丙醇(2%)、对羟基苯甲酸酯混合物(2%)、香薰混合物 1(2%)和新霉素(2%)。阳性反应的大多数患者为女性。

结论

本研究代表了老挝人群首次有记录的斑贴试验结果。希望这些发现将有助于临床医生为特应性皮炎患儿的家属提供有关常见过敏原的建议,并为该人群的接触性皮炎的未来研究提供信息。

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