大环内酯类药物在上呼吸道感染治疗中的地位
The Place of Macrolides in the Treatment of Upper Respiratory Tract Infections.
作者信息
Gómez-Barreto D
机构信息
Servicio de Contagiosos IV, Hospital Infantil de México, Mexico City, Mexico.
出版信息
Drug Investig. 1991;3(Suppl 3):17-20. doi: 10.1007/BF03258330. Epub 2012 Oct 26.
Abstract
The majority of all acute upper respiratory tract infections (URTIs) are viral in aetiology. Bacterial infection, either as a prime cause or secondary to the initial viral infection, can be effectively eradicated with appropriate drug therapy. A course of penicillin is usually effective in cases of acute tonsillitis, pharyngitis, otitis media and sinusitis. Macrolide antibiotics may be prescribed as an alternative, especially if β-lactamase-producing strains are present. Roxithromycin achieves high tissue concentrations, and cure rates between 85 and 100% have been reported in various URTIs.
摘要
大多数急性上呼吸道感染（URTIs）的病因是病毒。细菌感染，无论是作为主要病因还是继发于初始病毒感染，都可以通过适当的药物治疗有效根除。青霉素疗程通常对急性扁桃体炎、咽炎、中耳炎和鼻窦炎有效。大环内酯类抗生素可作为替代药物开出处方，特别是如果存在产β-内酰胺酶菌株。罗红霉素可达到较高的组织浓度，并且在各种上呼吸道感染中报告的治愈率在85%至100%之间。
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Ann Otol Rhinol Laryngol. 1981 May-Jun;90(3 Pt 1):261-3. doi: 10.1177/000348948109000313.
2
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N Engl J Med. 1983 Jun 16;308(24):1443-7. doi: 10.1056/NEJM198306163082403.
3
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JAMA. 1985 Mar 1;253(9):1271-4. doi: 10.1001/jama.253.9.1271.
4
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5
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6
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J Antimicrob Chemother. 1988 Oct;22(4):549-56. doi: 10.1093/jac/22.4.549.
7
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8
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Pediatrics. 1975 Apr;55(4):552-6.
9
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