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严重急性呼吸综合征冠状病毒(SARS-CoV)

Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV).

作者信息

Tong Tommy R

机构信息

Department of Pathology, Princess Margaret Hospital, Laichikok, Kowloon, Hong Kong, China.

出版信息

Perspect Med Virol. 2006;16:43-95. doi: 10.1016/S0168-7069(06)16004-8. Epub 2006 Nov 28.

Abstract

Severe acute respiratory syndrome (SARS) is caused by a coronavirus (CoV), SARSCoV. SARS-CoV belongs to the family Coronaviridae, which are enveloped RNA viruses in the order Nidovirales. Global research efforts are continuing to increase the understanding of the virus, the pathogenesis of the disease it causes (SARS), and the "heterogeneity of individual infectiousness" as well as shedding light on how to prepare for other emerging viral diseases. Promising drugs and vaccines have been identified. The milestones achieved have resulted from a truly international effort. Molecular studies dissected the adaptation of this virus as it jumped from an intermediary animal, the civet, to humans, thus providing valuable insights into processes of molecular emergence.

摘要

严重急性呼吸综合征(SARS)由一种冠状病毒(SARS-CoV)引起。SARS-CoV属于冠状病毒科,该科病毒是巢病毒目下的包膜RNA病毒。全球的研究工作仍在持续开展,以加深对该病毒、其所引发疾病(SARS)的发病机制、“个体传染性的异质性”的理解,并为应对其他新出现的病毒性疾病提供思路。已确定了有前景的药物和疫苗。所取得的这些里程碑式成果源于一项真正的国际合作努力。分子研究剖析了这种病毒从中间宿主果子狸传播到人类的过程中的适应性,从而为分子起源过程提供了宝贵的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/303b/7114587/689a069760a9/gr1.jpg

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