Deville Sebastien, Arous Juliette Ben, Ionkoff Ghislaine, Kukushkin François Bertranda Sergey, Baybikov Taufik, Borisov Vladimir, Dupuis Laurent
SEPPIC, 22 Terrasse Bellini, Paris La Défense, 92806 Puteaux Cedex, France.
FGI "Federal Centre for Animal Health" (FGI "ARRIAH"), Yur'evets, 600901 Vladimir, Russia.
Procedia Vaccinol. 2012;6:134-140. doi: 10.1016/j.provac.2012.04.018. Epub 2012 May 2.
PRRSV live vaccines are widely used in pig farming practice and are usually not adjuvanted. For safety issues, it would be useful to reduce the antigenic load of such vaccines while preserving their efficacy. In this study we show that the addition of polymer or oil adjuvants in a PRRS live vaccine enhanced the protection to challenge of vaccinated animals compared to a non-adjuvanted commercial reference. Moreover, for both types of adjuvants, despite lower antibody titers, the protection to challenge given by the adjuvanted vaccine containing only 50% of the antigen load was equivalent to the protection given by the non-adjuvanted vaccine. These results demonstrate that the addition of relevant adjuvants can enhance the efficacy of the protection conferred to animals by live vaccines.
猪繁殖与呼吸综合征病毒（PRRSV）活疫苗在养猪生产实践中广泛使用，且通常不添加佐剂。出于安全考虑，在保持疫苗效力的同时降低此类疫苗的抗原负荷将很有帮助。在本研究中，我们发现，与未添加佐剂的市售对照疫苗相比，在PRRSV活疫苗中添加聚合物或油佐剂可增强接种动物对攻毒的保护作用。此外，对于这两种佐剂，尽管抗体滴度较低，但仅含50%抗原负荷的佐剂疫苗对攻毒的保护作用与未添加佐剂的疫苗相当。这些结果表明，添加相关佐剂可增强活疫苗对动物的保护效力。
