Institute of Cardiovascular Physiology and Pathophysiology, Ludwig-Maximilians-University Munich, Planegg-Martinsried, Germany.
Eur J Clin Invest. 2020 Jun;50(6):e13237. doi: 10.1111/eci.13237. Epub 2020 May 6.
Recruitment of neutrophils from the intravascular compartment into injured tissue is an essential component of the inflammatory response. It involves intracellular trafficking of vesicles within neutrophils and endothelial cells, both containing numerous proteins that have to be distributed in a tightly controlled and precise spatiotemporal fashion during the recruitment process. Rab proteins, a family of small GTPases, together with their effectors, are the key players in guiding and regulating the intracellular vesicle trafficking machinery during neutrophil recruitment. This review will provide a short overview on this process and highlight new findings as well as current controversies in the field.
从血管腔内向损伤组织募集中性粒细胞是炎症反应的一个重要组成部分。它涉及到中性粒细胞和内皮细胞内囊泡的细胞内运输，其中包含许多蛋白质，这些蛋白质在募集过程中必须以紧密控制和精确的时空方式分布。Rab 蛋白是小 GTPases 家族的成员，与其效应蛋白一起，是指导和调节中性粒细胞募集过程中细胞内囊泡运输机制的关键因素。本文将对这一过程进行简要概述，并强调该领域的新发现和当前的争议。
