下丘脑外侧的谷氨酸能快速放电小白蛋白神经元：行为相关的电生理特性
Glutamatergic fast-spiking parvalbumin neurons in the lateral hypothalamus: Electrophysiological properties to behavior.
作者信息
Siemian Justin N, Sarsfield Sarah, Aponte Yeka
机构信息
Neuronal Circuits and Behavior Unit, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD 21224-6823, USA.
Neuronal Circuits and Behavior Unit, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD 21224-6823, USA; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
出版信息
Physiol Behav. 2020 Jul 1;221:112912. doi: 10.1016/j.physbeh.2020.112912. Epub 2020 Apr 11.
Throughout the central nervous system, neurons expressing the calcium-binding protein parvalbumin have been typically classified as GABAergic with fast-spiking characteristics. However, new methods that allow systematic characterization of the cytoarchitectural organization, connectivity, activity patterns, neurotransmitter nature, and function of genetically-distinct cell types have revealed populations of parvalbumin-positive neurons that are glutamatergic. Remarkably, such findings challenge longstanding concepts that fast-spiking neurons are exclusively GABAergic, suggesting conservation of the fast-spiking phenotype across at least two neurotransmitter systems. This review focuses on the recent advancements that have begun to reveal the functional roles of lateral hypothalamic parvalbumin-positive neurons in regulating behaviors essential for survival.
在整个中枢神经系统中，表达钙结合蛋白小白蛋白的神经元通常被归类为具有快速放电特征的γ-氨基丁酸能神经元。然而，新方法能够系统地表征细胞结构组织、连接性、活动模式、神经递质性质以及基因不同细胞类型的功能，这些方法揭示了一些表达小白蛋白的谷氨酸能神经元群体。值得注意的是，这些发现挑战了长期以来的观念，即快速放电神经元完全是γ-氨基丁酸能的，这表明至少在两个神经递质系统中存在快速放电表型的保守性。本综述聚焦于最近的进展，这些进展已开始揭示下丘脑外侧表达小白蛋白的神经元在调节生存所必需的行为中的功能作用。
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