de Abreu Murilo S, Giacomini Ana C V V, Genario Rafael, Rech Nathália, Carboni Júlia, Lakstygal Anton M, Amstislavskaya Tamara G, Demin Konstantin A, Leonard Brian E, Vlok Marli, Harvey Brian H, Piato Angelo, Barcellos Leonardo J G, Kalueff Allan V
Bioscience Institute, University of Passo Fundo (UPF), Passo Fundo, RS, Brazil; The International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, LA, USA.
Bioscience Institute, University of Passo Fundo (UPF), Passo Fundo, RS, Brazil; Postgraduate Program in Environmental Sciences, University of Passo Fundo (UPF), Passo Fundo, Brazil.
Pharmacol Biochem Behav. 2020 Jun;193:172928. doi: 10.1016/j.pbb.2020.172928. Epub 2020 Apr 11.
Acute and chronic stressors are common triggers of human mental illnesses. Experimental animal models and their cross-species translation to humans are critical for understanding of the pathogenesis of stress-related psychiatric disorders. Mounting evidence suggests that both pharmacological and non-pharmacological approaches can be efficient in treating these disorders. Here, we analyze human, rodent and zebrafish (Danio rerio) data to compare the impact of non-pharmacological and pharmacological therapies of stress-related psychopathologies. Emphasizing the likely synergism and interplay between pharmacological and environmental factors in mitigating daily stress both clinically and in experimental models, we argue that environmental enrichment emerges as a promising complementary therapy for stress-induced disorders across taxa. We also call for a broader use of novel model organisms, such as zebrafish, to study such treatments and their potential interplay.
急性和慢性应激源是人类精神疾病的常见触发因素。实验动物模型及其向人类的跨物种转化对于理解应激相关精神障碍的发病机制至关重要。越来越多的证据表明，药物治疗和非药物治疗方法在治疗这些疾病方面都可能有效。在这里，我们分析人类、啮齿动物和斑马鱼（Danio rerio）的数据，以比较应激相关精神病理学的非药物和药物治疗的影响。强调药物和环境因素在临床和实验模型中减轻日常应激方面可能存在的协同作用和相互影响，我们认为环境富集作为一种有前景的跨物种应激诱导障碍补充疗法而出现。我们还呼吁更广泛地使用新型模式生物，如斑马鱼，来研究此类治疗方法及其潜在的相互作用。
