Department of Computer Science, University of Warwick, Coventry, CV4 7AL, UK.
Institute of Science and Technology for Brain-inspired Intelligence, Fudan University, Shanghai, 200433, China; Department of Computer Science, University of Warwick, Coventry, CV4 7AL, UK; Oxford Centre for Computational Neuroscience, Oxford, UK.
Neuroimage. 2020 Jul 15;215:116845. doi: 10.1016/j.neuroimage.2020.116845. Epub 2020 Apr 11.
Sensation-seeking is a multifaceted personality trait with components that include experience-seeking, thrill and adventure seeking, disinhibition, and susceptibility to boredom, and is an aspect of impulsiveness. We analysed brain regions involved in sensation-seeking in a large-scale study with 414 participants and showed that the sensation-seeking score could be optimally predicted from the functional connectivity with typically (in different participants) 18 links between brain areas (measured in the resting state with fMRI) with correlation r = 0.34 (p = 7.3 × 10) between the predicted and actual sensation-seeking score across all participants. Interestingly, 8 of the 11 links that were common for all participants were between the medial orbitofrontal cortex and the anterior cingulate cortex and yielded a prediction accuracy r = 0.30 (p = 4.8 × 10). We propose that this important aspect of personality, sensation-seeking, reflects a strong effect of reward (in which the medial orbitofrontal cortex is implicated) on promoting actions to obtain rewards (in which the anterior cingulate cortex is implicated). Risk-taking was found to have a moderate correlation with sensation-seeking (r = 0.49, p = 3.9 × 10), and three of these functional connectivities were significantly correlated (p < 0.05) with the overall risk-taking score. This discovery helps to show how the medial orbitofrontal and anterior cingulate cortices influence behaviour and personality, and indicate that sensation-seeking can involve in part the medial orbitofrontal cortex reward system, which can thereby become associated with risk-taking and a type of impulsiveness.
寻求刺激是一种多方面的人格特质，其组成部分包括寻求体验、寻求刺激和冒险、抑制解除和对无聊敏感，是冲动的一个方面。我们在一项涉及 414 名参与者的大规模研究中分析了与寻求刺激相关的大脑区域，结果表明，通过对静息状态 fMRI 测量的大脑区域之间的 18 个典型（在不同参与者中）连接的功能连接，可最佳地预测寻求刺激的得分（相关系数 r = 0.34，p = 7.3×10-4）。有趣的是，11 个共同链接中的 8 个是在眶额内侧皮质和前扣带皮质之间，对所有参与者的预测和实际寻求刺激得分的预测准确性 r = 0.30（p = 4.8×10-3）。我们提出，这种人格的重要方面，即寻求刺激，反映了奖励（眶额内侧皮质涉及）对促进获取奖励的行为的强烈影响（前扣带皮质涉及）。风险承担与寻求刺激有中度相关性（r = 0.49，p = 3.9×10-3），其中三个功能连接与总体风险承担得分显著相关（p < 0.05）。这一发现有助于表明眶额内侧和前扣带皮质如何影响行为和人格，并表明寻求刺激可能部分涉及眶额内侧皮质奖励系统，从而与风险承担和冲动的一种类型相关联。
