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Statins in coronavirus outbreak: It's time for experimental and clinical studies.

作者信息

Bifulco Maurizio, Gazzerro Patrizia

机构信息

Department of Molecular Medicine and Medical Biotechnologies, University of Naples "Federico II", 80131, Naples, Italy.

Department of Pharmacy, University of Salerno, 84084, Fisciano, SA, Italy.

出版信息

Pharmacol Res. 2020 Jun;156:104803. doi: 10.1016/j.phrs.2020.104803. Epub 2020 Apr 11.

DOI:10.1016/j.phrs.2020.104803
PMID:32289478
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7151298/
Abstract
摘要

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本文引用的文献

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Atorvastatin restricts the ability of influenza virus to generate lipid droplets and severely suppresses the replication of the virus.阿托伐他汀限制了流感病毒生成脂滴的能力，并严重抑制了病毒的复制。
FASEB J. 2019 Aug;33(8):9516-9525. doi: 10.1096/fj.201900428RR. Epub 2019 May 24.
2
Modulation of sterol biosynthesis regulates viral replication and cytokine production in influenza A virus infected human alveolar epithelial cells.固醇生物合成的调节可调控甲型流感病毒感染的人肺泡上皮细胞中的病毒复制和细胞因子产生。
Antiviral Res. 2015 Jul;119:1-7. doi: 10.1016/j.antiviral.2015.04.005. Epub 2015 Apr 13.
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Mechanisms of action and efficacy of statins against influenza.他汀类药物抗流感的作用机制及疗效
Biomed Res Int. 2014;2014:872370. doi: 10.1155/2014/872370. Epub 2014 Nov 11.
4
Statin: new life for an old drug.他汀类药物：旧药新用途。
Pharmacol Res. 2014 Oct;88:1-2. doi: 10.1016/j.phrs.2014.06.005. Epub 2014 Jul 14.
5
Systematic review and meta-analysis on the association between outpatient statins use and infectious disease-related mortality.系统评价和荟萃分析：门诊使用他汀类药物与感染性疾病相关死亡率的关系。
PLoS One. 2012;7(12):e51548. doi: 10.1371/journal.pone.0051548. Epub 2012 Dec 17.
6
Statins and prevention of infections: systematic review and meta-analysis of data from large randomised placebo controlled trials.他汀类药物与感染预防：来自大型随机安慰剂对照试验的系统评价和荟萃分析数据。
BMJ. 2011 Nov 29;343:d7281. doi: 10.1136/bmj.d7281.
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Influenza and COPD mortality protection as pleiotropic, dose-dependent effects of statins.流感和慢性阻塞性肺疾病死亡率的保护作用是他汀类药物的多效性、剂量依赖性效应。
Chest. 2007 Apr;131(4):1006-12. doi: 10.1378/chest.06-1997.