Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital, Hvidovre, Denmark; Department of Rehabilitation Medicine, Keio University School of Medicine, Tokyo, Japan.
Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital, Hvidovre, Denmark; Department of Neurology, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark; Institute for Clinical Medicine, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark.
Brain Stimul. 2020 May-Jun;13(3):815-818. doi: 10.1016/j.brs.2020.02.015. Epub 2020 Feb 21.
Recording electroencephalography (EEG) from the targeted cortex immediately before and after focal transcranial electrical stimulation (TES) remains a challenge.
We introduce a hybrid stimulation-recording approach where a single EEG electrode is inserted into the inner electrode of a double-ring montage for focal TES. The new combined electrode was placed at the C3 position of the EEG 10-20 system. Neuronal activity was recorded in two volunteers before and after 20 Hz alternating-current TES at peak-to-peak intensities of 1 and 2 mA. TES-induced electric field distributions were simulated with SIMNIBS software.
Using the hybrid stimulation-recording set-up, EEG activity was successfully recorded directly before and after TES. Simulations revealed comparable electrical fields in the stimulated cortex for the pseudomonopolar montage with and without embedded EEG electrode.
The hybrid TES-EEG approach can be used to probe after-effects of focal TES on neuronal activity in the targeted cortex.
在进行聚焦经颅电刺激（TES）之前和之后，从目标皮层记录脑电图（EEG）仍然是一个挑战。
我们引入了一种混合刺激-记录方法，其中一个 EEG 电极插入双环电极的内电极中进行聚焦 TES。新的组合电极放置在 EEG 10-20 系统的 C3 位置。在两名志愿者中，在 1 和 2 mA 峰峰值的 20 Hz 交流电 TES 前后记录神经元活动。使用 SIMNIBS 软件模拟 TES 诱导的电场分布。
使用混合刺激-记录设置，成功地在 TES 之前和之后直接记录 EEG 活动。模拟结果显示，对于带有和不带有嵌入式 EEG 电极的伪单极电极，刺激皮层中的电场具有可比性。
混合 TES-EEG 方法可用于探测聚焦 TES 对目标皮层神经元活动的后效。
