Centre for Human Genetics, Hazara University, Mansehra, Pakistan,
Neurodegener Dis. 2019;19(5-6):211-217. doi: 10.1159/000506742. Epub 2020 Apr 14.
Parkinson's disease (PD) is one of the most common neurological disorders that mostly affect aged individuals. The common symptoms of PD are rest tremor, bradykinesia, and rigidity.
The present study was devised to find out the clinical features and risk factors associated with PD in a population of Khyber Pakhtunkhwa.
A total of 600 PD patients and 1,200 control individuals took part in this study. The participants filled out a standard questionnaire.
This study found a significant association between PD and exposure to pesticides (p < 0.0001) and doing work on farms (p < 0.0001). The use of aldrin was significantly associated with PD (p < 0.0001). Furthermore, we also found that PD status was associated with individuals who have a history of depression, hypertension, head injury, and Alzheimer's disease. This study also showed that the PD rate was lower in those who were using tobacco products.
In this case-control study, we revealed some environmental and medical conditions that are linked with PD. To control the disease, we must minimize exposure to pesticides, and the government and scientific community should play their role.
帕金森病（PD）是最常见的神经退行性疾病之一，主要影响老年人。PD 的常见症状是静止性震颤、运动迟缓、和僵硬。
本研究旨在发现俾路支省 PD 患者的临床特征和相关风险因素。
本研究纳入了 600 名 PD 患者和 1200 名对照者。参与者填写了一份标准问卷。
本研究发现 PD 与接触杀虫剂（p<0.0001）和农场工作（p<0.0001）之间存在显著关联。艾氏剂的使用与 PD 显著相关（p<0.0001）。此外，我们还发现 PD 状态与有抑郁、高血压、头部受伤和阿尔茨海默病病史的个体有关。本研究还表明，使用烟草产品的个体 PD 发生率较低。
在这项病例对照研究中，我们揭示了一些与 PD 相关的环境和医疗条件。为了控制这种疾病，我们必须尽量减少接触杀虫剂，政府和科学界应发挥作用。
