Curtis J J, Bhathena D, Lucas B A, McRoberts J W, Luke R G
Clin Nephrol. 1977 Mar;7(3):120-4.
Two kidneys were harvested from a cadaver donor and subjected to pulsatile perfusion in an identical fashion with a perfusate which was free of cytotoxic antibody. Classical 'hyperacute rejection' occurred in the right kidney when transplanted into a male patient with no previous blood transfusion or transplants, and repeatedly negative tests for cytotoxic antibody. The left kidney was not transplanted and was examined by light, electron, and immunofluorescence microscopy as was the immediately removed, transplanted kidney. Despite the absence of any immunological pathogenetic mechanism in the non-transplanted kidney, virtually identical changes of 'hyperacute rejection' were seen in both kidneys. Thus,even technically satisfactory perfusion may cause a syndrome of 'hyperacute graft failure' secondary to non-immunologically mediated perfusion injury.
从一名尸体供体获取了两个肾脏，并用不含细胞毒性抗体的灌注液以相同方式对其进行搏动灌注。当将右肾移植到一名既往无输血或移植史且细胞毒性抗体检测反复呈阴性的男性患者体内时，发生了典型的“超急性排斥反应”。左肾未进行移植，与立即切除的移植肾一样，通过光镜、电镜和免疫荧光显微镜进行检查。尽管未移植的肾脏不存在任何免疫发病机制，但在两个肾脏中均观察到了几乎相同的“超急性排斥反应”变化。因此，即使在技术上令人满意的灌注也可能导致继发于非免疫介导的灌注损伤的“超急性移植物功能衰竭”综合征。
