盐皮质激素不参与基因性高血压LH大鼠新生期胸腺切除的降压作用。

Mineralocorticoids are not involved in the antihypertensive effect of neonatal thymectomy in the genetically hypertensive LH rat.

Bataillard A, Gomez-Sanchez C E, Vincent M, Touraine J L, Sassard J

Department of Physiology and Clinical Pharmacology, CNRS UA 606, Faculty of Pharmacy, Lyon, France.

Clin Exp Pharmacol Physiol. 1988 Nov;15(11):875-82. doi: 10.1111/j.1440-1681.1988.tb01030.x.

Abstract

In order to determine whether the antihypertensive effect of neonatal thymectomy in genetically hypertensive rats could be mediated through altered adrenal function, systolic blood pressure (SBP) and urinary excretion of deoxycorticosterone (DOC), corticosterone (B) and aldosterone were measured in thymectomized hypertensive (LH), normotensive (LN) and low-blood pressure (LL) rats of the Lyon strain. Sham-operated animals served as controls. 2. Neonatal thymectomy prevented the spontaneous increase of SBP in LH rats while it slightly decreased the SBP of LN and did not change that of LL rats. 3. Five week old sham-operated LH rats exhibited an increased urinary excretion of DOC and a decreased excretion of B compared with both LN and LL controls. Thymectomy did not alter the urinary excretion of adrenal steroids in LN and LL rats. The urinary excretion of B was markedly enhanced in thymectomized LH rats whereas that of DOC remained unmodified. 4. These data suggested that the thymus could be involved in the development of hypertension in LH rats. 5. The antihypertensive effect of thymectomy did not seem to be mediated by a decreased mineralocorticoid production in the genetically hypertensive rat of the Lyon strain.

摘要

为了确定基因性高血压大鼠新生期胸腺切除的降压作用是否可通过肾上腺功能改变来介导，我们测定了Lyon品系胸腺切除的高血压（LH）、正常血压（LN）和低血压（LL）大鼠的收缩压（SBP）以及脱氧皮质酮（DOC）、皮质酮（B）和醛固酮的尿排泄量。假手术动物作为对照。2. 新生期胸腺切除可阻止LH大鼠SBP的自发性升高，而使LN大鼠的SBP略有降低，对LL大鼠的SBP则无影响。3. 与LN和LL对照相比，5周龄假手术的LH大鼠DOC尿排泄量增加，B尿排泄量减少。胸腺切除对LN和LL大鼠肾上腺类固醇的尿排泄无影响。胸腺切除的LH大鼠B的尿排泄量明显增加，而DOC的尿排泄量未改变。4. 这些数据提示胸腺可能参与LH大鼠高血压的发生。5. 在Lyon品系的基因性高血压大鼠中，胸腺切除的降压作用似乎不是由盐皮质激素生成减少所介导的。