Bataillard A, Freiche J C, Vincent M, Sassard J, Touraine J L
Thymus. 1986;8(6):321-30.
Genetically hypertensive (LH), normotensive (LN), and low blood pressure (LL) rats of the Lyon strains have been simultaneously selected according to their systolic blood pressure (SBP). SBP and immunological parameters were investigated in 5 week-old rats. SBP reached 99 +/- 2 mmHg in LL, 108 +/- 2 mmHg in LN and 122 +/- 4 mmHg in LH. White blood cell and lymphocyte counts, thymus and spleen histology, percentages of T cells and subsets of T cells in these organs were not modified by genetic hypertension. The blastogenic responses to mitogens (Con A and PWM) of the LH rat thymocytes were similar to those observed in LN or LL rats. By contrast, the proliferative response of splenocytes to PWM was positively correlated (r = 0.93) with SBP level. In additional experiments we demonstrated that, besides the immune defect induced by neonatal thymectomy, the removal of the thymus at birth prevented the spontaneous increase of SBP in LH strains (102 +/- 2 mmHg instead of 122 +/- 4 mmHg), while only a slight decrease or no alteration was seen in LN and LL thymectomized rats. This antihypertensive effect tended to maintain SBP at a common level in the 3 strains. These results suggest that the thymus may be involved in the development of genetic hypertension.
根据收缩压（SBP）同时选择了Lyon品系的遗传性高血压（LH）、正常血压（LN）和低血压（LL）大鼠。对5周龄大鼠的SBP和免疫参数进行了研究。LL大鼠的SBP达到99±2 mmHg，LN大鼠为108±2 mmHg，LH大鼠为122±4 mmHg。遗传高血压并未改变这些大鼠的白细胞和淋巴细胞计数、胸腺和脾脏组织学、T细胞百分比以及这些器官中T细胞亚群。LH大鼠胸腺细胞对有丝分裂原（刀豆蛋白A和美洲商陆有丝分裂原）的增殖反应与LN或LL大鼠中观察到的相似。相比之下，脾细胞对美洲商陆有丝分裂原的增殖反应与SBP水平呈正相关（r = 0.93）。在其他实验中我们证明，除了新生期胸腺切除诱导的免疫缺陷外，出生时切除胸腺可防止LH品系大鼠SBP的自发升高（从122±4 mmHg降至102±2 mmHg），而LN和LL胸腺切除大鼠仅出现轻微下降或无变化。这种降压作用倾向于使3个品系的SBP维持在一个共同水平。这些结果表明胸腺可能参与了遗传性高血压的发生发展。
