Department of Hygiene, Epidemiology, Ergonomics and Postgraduate Training, Division of Ergonomics and Exercise Physiology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, 85-094 Bydgoszcz, Poland.
Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford OX3 9DU, UK.
Medicina (Kaunas). 2020 Apr 10;56(4):172. doi: 10.3390/medicina56040172.
: This is the first study to investigate the effect of high-flow oxygen therapy, using a normobaric chamber on cognitive, biochemical (oxidative stress parameters and the level of neurotrophins), cardiovascular and autonomic functioning. : 17 healthy volunteers, eight males and nine females, with a mean age of 37.5 years, were examined. The experimental study involved ten two-hour exposures in a normobaric chamber with a total pressure of 1500 hPa (32–40 kPa partial pressure of oxygen, 0.7–2 kPa of carbon dioxide and 0.4–0.5 kPa of hydrogen). Cognitive function was assessed by using Trail Making Test parts A, B and difference in results of these tests (TMT A, TMT B and TMT B-A); California Verbal Learning Test (CVLT); Digit symbol substitution test (DSST); and Digit Span (DS). Fatigue (Fatigue Severity Scale (FSS)), cardiovascular, autonomic and baroreceptor functioning (Task Force Monitor) and biochemical parameters were measured before and after intervention. : After 10 sessions in the normobaric chamber, significant decreases in weight, caused mainly by body fat % decrease (24.86 vs. 23.93%, = 0.04 were observed. TMT part A and B results improved ( = 0.0007 and = 0.001, respectively). In contrast, there was no statistically significant influence on TMT B-A. Moreover, decrease in the number of symbols left after a one-minute test in DSST was noted ( = 0.0001). The mean number of words correctly recalled in the CVLT Long Delay Free Recall test improved ( = 0.002), and a reduction in fatigue was observed ( = 0.001). Biochemical tests showed a reduction in levels of malondialdehyde ( < 0.001), with increased levels of Cu Zn superoxide dismutase ( < 0.001), Neurotrophin 4 ( = 0.0001) and brain-derived neurotrophic factor (p = 0.001). A significant increase in nitric oxide synthase 2 (Z = 2.29, = 0.02) and Club cell secretory protein ( = 0.015) was also noted. Baroreceptor function was significantly improved after normobaric exposures ( = 0.003). Significant effect of normobaric exposures and BDNF in CVLT Long Delay Free Recall was noted. : This study demonstrates that 10 exposures in a normobaric chamber have a positive impact on visual information and set-shifting processing speed and increase auditory-verbal short-term memory, neurotrophic levels and baroreceptor function. A response of the respiratory tract to oxidative stress was also noted. There is a need to rigorously examine the safety of normobaric therapy. Further studies should be carried out with physician examination, both pre and post treatment.
这是第一项研究，旨在调查常压氧疗（使用常压舱）对认知、生化（氧化应激参数和神经营养因子水平）、心血管和自主功能的影响。 17 名健康志愿者，8 名男性和 9 名女性，平均年龄 37.5 岁，接受了检查。实验研究涉及在总压力为 1500 毫巴（32-40 千帕氧分压、0.7-2 千帕二氧化碳分压和 0.4-0.5 千帕氢气分压）的常压舱中进行 10 次 2 小时暴露。认知功能通过使用连线测试 A、B 和这些测试结果的差异（TMT A、TMT B 和 TMT B-A）、加利福尼亚语言学习测试（CVLT）、数字符号替代测试（DSST）和数字跨度（DS）进行评估。疲劳（疲劳严重程度量表（FSS））、心血管、自主和压力感受器功能（Task Force Monitor）和生化参数在干预前后进行测量。 在常压舱进行 10 次治疗后，体重显著下降，主要是由于体脂百分比下降（24.86%对 23.93%， = 0.04）。TMT A 和 B 的结果有所改善（分别为 0.0007 和 0.001）。相反，TMT B-A 没有统计学意义的影响。此外，DSST 中一分钟测试后留下的符号数量减少（ = 0.0001）。CVLT 长时延迟自由回忆测试中正确回忆的单词数量增加（ = 0.002），疲劳减轻（ = 0.001）。生化测试显示丙二醛水平降低（ < 0.001），CuZn 超氧化物歧化酶水平升高（ < 0.001），神经生长因子 4 （ = 0.0001）和脑源性神经营养因子（p = 0.001）。还观察到一氧化氮合酶 2（Z = 2.29， = 0.02）和 Club 细胞分泌蛋白（ = 0.015）的显著增加。常压暴露后，压力感受器功能显著改善（ = 0.003）。常压暴露和 BDNF 在 CVLT 长时延迟自由回忆中均有显著影响。 这项研究表明，10 次常压舱治疗对视觉信息和转换处理速度有积极影响，并增加了听觉语言短期记忆、神经营养因子水平和压力感受器功能。还观察到呼吸道对氧化应激的反应。需要严格检查常压治疗的安全性。应进行进一步的研究，包括治疗前和治疗后的医生检查。
