超重或肥胖儿童久坐行为与脑结构及智力的关联：主动大脑项目
Association of Sedentary Behavior with Brain Structure and Intelligence in Children with Overweight or Obesity: The ActiveBrains Project.
作者信息
Zavala-Crichton Juan Pablo, Esteban-Cornejo Irene, Solis-Urra Patricio, Mora-Gonzalez José, Cadenas-Sanchez Cristina, Rodriguez-Ayllon María, Migueles Jairo H, Molina-Garcia Pablo, Verdejo-Roman Juan, Kramer Arthur F, Hillman Charles H, Erickson Kirk I, Catena Andrés, Ortega Francisco B
机构信息
PROFITH "PROmoting FITness and Health Through Physical Activity" Research Group, Sport and Health University Research Institute (iMUDS), Department of Physical and Sports Education, Faculty of Sport Sciences, University of Granada, 18071 Granada, Spain.
Faculty of Education and Social Sciences, Universidad Andres Bello, Viña del Mar 2531015, Chile.
出版信息
J Clin Med. 2020 Apr 12;9(4):1101. doi: 10.3390/jcm9041101.
UNLABELLED
We investigated the associations of different sedentary behaviors (SB) with gray matter volume and we tested whether SB related to gray matter volume is associated with intelligence.
METHODS
99 children with overweight or obesity aged 8-11 years participated in this cross-sectional study. SB was measured using the Youth Activity Profile-Spain questionnaire. T1-weighted images were acquired with a 3.0 T Magnetom Tim Trio system. Intelligence was assessed with the Kaufman Brief Test. Whole-brain voxel-wise multiple regression models were used to test the associations of each SB with gray matter volume.
RESULTS
Watching TV was associated with lower gray matter volume in six brain regions (β ranging -0.314 to -0.489 and cluster size 106 to 323 voxels; < 0.001), playing video games in three brain regions (β ranging -0.391 to -0.359, and cluster size 96 to 461 voxels; < 0.001) and total sedentary time in two brain regions (β ranging -0.341 to -0.352, and cluster size 897 to 2455 voxels; < 0.001). No brain regions showed a significant positive association (all > 0.05). Two brain regions were related, or borderline related, to intelligence.
CONCLUSIONS
SB could have the potential to negatively influence brain structure and, in turn, intelligence in children with overweight/obesity.
未标注
我们研究了不同久坐行为（SB）与灰质体积之间的关联，并测试了与灰质体积相关的SB是否与智力有关。
方法
99名8至11岁超重或肥胖儿童参与了这项横断面研究。使用西班牙青少年活动概况问卷测量SB。采用3.0T Magnetom Tim Trio系统采集T1加权图像。用考夫曼简易测验评估智力。采用全脑体素水平多元回归模型测试每种SB与灰质体积之间的关联。
结果
看电视与六个脑区灰质体积降低有关（β范围为-0.314至-0.489，聚类大小为106至323体素；P<0.001），玩电子游戏与三个脑区灰质体积降低有关（β范围为-0.391至-0.359，聚类大小为96至461体素；P<0.001），总久坐时间与两个脑区灰质体积降低有关（β范围为-0.341至-0.352，聚类大小为897至2455体素；P<0.001）。没有脑区显示出显著的正相关（所有P>0.05）。两个脑区与智力相关或临界相关。
结论
久坐行为可能会对超重/肥胖儿童的脑结构产生负面影响，进而影响其智力。
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