Jiang Xue, Tang Le, Zhang Yonghui, Bai Yiwen, Luo Huihuan, Wang Rui, Bi Xia, Chen Renjie, Wang Xueqiang
School of Exercise and Health, Shanghai University of Sport, Shanghai, China.
Pain in Motion Research Group (PAIN), Department of Physiotherapy, Human Physiology and Anatomy, Faculty of Physical Education & Physiotherapy, Vrije Universiteit Brussel, Brussels, Belgium.
BMC Public Health. 2024 Oct 1;24(1):2685. doi: 10.1186/s12889-024-20188-3.
The relationship between sedentary time, physical activity, and chronic back pain remains unclear. The study aims to investigate whether sedentary time and physical activity predict chronic back pain and morphological brain changes.
This cohort study recruited adults aged 37-73 years enrolled between 2006 and 2010, with follow-up until 2014. The total cohort comprised 33,402 participants (mean age: 54.53). Data were collected on daily sedentary time, physical activity, lifestyle factors, and health outcomes.
After nearly 8-year follow-up, 3,006 individuals (9.00%) reported chronic back pain in total. Individuals with daily sedentary time exceeding 6 h had a 33% higher risk of chronic back pain compared to those with sedentary time of 2 h or less (RR, 1.33, 95%CI, 1.17-1.52). Sedentary time was also associated with decreased grey matter volume in several brain regions, including bilateral primary somatosensory cortex (S1), secondary somatosensory cortex, putamen, primary motor cortex (M1), insula, hippocampus, amygdala, as well as right supplementary motor area, left medial frontal cortex, and right anterior cingulate cortex (FDR-corrected p-value < 0.05). Compared to individuals who sat for more than 6 h with light physical activity, those engaging in moderate physical activity with sedentary time of 2 h or less (RR, 0.71, 95%CI, 0.52-0.99) exhibited a significant decrease in chronic back pain risk. In addition, replacing sedentary time with equivalent amount of physical activity also demonstrated a reduction in the risk of chronic back pain (RR, 0.87, 95%CI, 0.77-0.99) and increased the reginal grey matter volumes including the amygdala, insula, M1, putamen and S1.
Prolonged sedentary time is associated with heightened risks of chronic back pain and deterioration in brain health.
久坐时间、身体活动与慢性背痛之间的关系仍不明确。本研究旨在调查久坐时间和身体活动是否能预测慢性背痛及大脑形态变化。
这项队列研究招募了2006年至2010年间登记的37至73岁成年人，随访至2014年。整个队列包括33402名参与者（平均年龄：54.53岁）。收集了每日久坐时间、身体活动、生活方式因素和健康结果的数据。
经过近8年的随访，共有3006人（9.00%）报告患有慢性背痛。每日久坐时间超过6小时的个体患慢性背痛的风险比久坐时间为2小时或更短的个体高33%（风险比，1.33；95%置信区间，1.17 - 1.52）。久坐时间还与几个脑区灰质体积减少有关，包括双侧初级体感皮层（S1）、次级体感皮层、壳核、初级运动皮层（M1）、岛叶、海马体、杏仁核，以及右侧辅助运动区、左侧内侧前额叶皮层和右侧前扣带回皮层（错误发现率校正p值 < 0.05）。与久坐超过6小时且身体活动量少的个体相比，进行中等强度身体活动且久坐时间为2小时或更短的个体（风险比，0.71；95%置信区间，0.52 - 0.99）慢性背痛风险显著降低。此外，用等量的身体活动替代久坐时间也显示出慢性背痛风险降低（风险比，0.87；95%置信区间，0.77 - 0.99），并增加了包括杏仁核、岛叶、M1、壳核和S1在内的脑区灰质体积。
久坐时间延长与慢性背痛风险增加和大脑健康恶化有关。
