Key Laboratory of Advanced Materials of Tropical Island Resources of Ministry of Education, School of Chemical Engineering and Technology, Hainan University, Haikou, Hainan, People's Republic of China.
Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan, People's Republic of China.
Nat Prod Res. 2021 Nov;35(21):3970-3976. doi: 10.1080/14786419.2020.1752210. Epub 2020 Apr 14.
A new ,-unsaturated 7-ketone sterol, 5,6-epoxy-3, 15-dihydroxy-(22,24)-ergosta-8(14),22-dien-7-one (), along with five known sterone derivatives, 5,6-epoxy-3,7-dihydroxy-(22,24)-ergosta-8(14),22-dien-15-one (), 5,6-epoxy-3,7,9-trihydroxy-(22,24)-ergosta-8(14),22-dien-15-one (), 3,9,15-trihydroxy-(22,24)-10(5→4)-abeo-ergosta-6,8(14),22-trien-5-one (), 3,15-dihydroxyl-(22,24)-ergosta-5,8(14),22-trien-7-one () and (22,24)-ergosta-4,6,8(14),22-tetraen-3,15-dione () were isolated from the mangrove-derived fungus sp. MGF222. Their structures were established on the basis of extensive spectroscopic data and comparison with the data of literature. Compound showed weak antibacterial activity against with the MIC value of 28.2 (±0.52) μM. Compound exhibited moderate antibacterial activity against with the MIC value of 14.6 (±0.47) μM.
一种新的，-不饱和 7-酮固醇，5,6-环氧-3,15-二羟基-(22,24)-麦角甾-8(14),22-二烯-7-酮 ()，以及五种已知的甾体衍生物，5,6-环氧-3,7-二羟基-(22,24)-麦角甾-8(14),22-二烯-15-酮 (), 5,6-环氧-3,7,9-三羟基-(22,24)-麦角甾-8(14),22-二烯-15-酮 (), 3,9,15-三羟基-(22,24)-10(5→4)-abeo-麦角甾-6,8(14),22-三烯-5-酮 (), 3,15-二羟基-(22,24)-麦角甾-5,8(14),22-三烯-7-酮 ()和(22,24)-麦角甾-4,6,8(14),22-四烯-3,15-二酮 ()从红树林来源的真菌 sp. MGF222 中分离得到。它们的结构是基于广泛的光谱数据和与文献数据的比较而建立的。化合物 对 显示出较弱的抗菌活性，MIC 值为 28.2(±0.52)μM。化合物 对 显示出中等抗菌活性，MIC 值为 14.6(±0.47)μM。
