Sorbitol in aortic endothelium of diabetic rats.
作者信息
Brolin S E, Naeser P
机构信息
Department of Medical Cell Biology, University of Uppsala, Sweden.
出版信息
Diabetes Res. 1988 Jun;8(2):59-61.
PMID:3229072
Abstract
Sorbitol metabolism of the endothelial cells of the aorta has been studied in normal and alloxan diabetic rats by the aid of a new time- and gradient governed elution method. In the normal rats the amount of sorbitol was small whereas in the diabetic animals the content was significantly increased (p less than 0.001). The activity of sorbitol-dehydrogenase was not changed. It is possible that a metabolic injury of endothelial cells induced by a glucose overload may be mediated by formation of sorbitol.
摘要
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引用本文的文献
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