胆囊癌中的表观遗传学标志物。
Epigenetic Biomarkers in Gallbladder Cancer.
机构信息
Centre for Genomics, Jiwaji University, Gwalior 474011, Madhya Pradesh, India.
出版信息
Trends Cancer. 2020 Jul;6(7):540-543. doi: 10.1016/j.trecan.2020.03.003. Epub 2020 Apr 11.
PMID:32291238
Abstract
Gallbladder cancer (GBC) is associated with various nongenetic and genetic factors. Lack of specific and sensitive diagnostic markers has significantly impacted the mortality of this disease. Here we discuss the recent discovery of epigenetic changes that show great promise as diagnostic biomarkers as well as potential therapeutic targets for GBC.
摘要
胆囊癌（GBC）与各种非遗传和遗传因素有关。缺乏特异性和敏感性诊断标志物显著影响了该疾病的死亡率。在这里，我们讨论了最近发现的表观遗传变化，这些变化作为诊断生物标志物以及胆囊癌潜在治疗靶点具有很大的潜力。
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