Ennever J, Riggan L J
University of Texas Dental Branch, Dental Science Institute, Houston 77225.
Cytobios. 1988;55(221):81-5.
This work tested the concept that thiol loss, proposed as a cause of animal ageing, occurs in ageing cultures of Bacterionema matruchotii. Paired comparisons were made between thiol levels of exponential- and stationary-phase cultures. Values for stationary phase were consistently and significantly (P less than 0.01) lower. If bacterial thiol loss is an effect of culture ageing rather than a cause, the same possibility must be considered with respect to tissue. However, if thiol loss is a cause of ageing, the role for thiol loss in tissue ageing would be strengthened. A major problem in the biology of ageing is to distinguish between cause and consequence. Bacterial culture could provide a relatively simple model for such inquiry.
这项研究验证了一个概念，即作为动物衰老原因而提出的硫醇损失，发生在衰老的牙龈内氏放线菌培养物中。对指数生长期和稳定期培养物的硫醇水平进行了配对比较。稳定期的值始终显著较低（P小于0.01）。如果细菌硫醇损失是培养物老化的结果而非原因，那么对于组织也必须考虑同样的可能性。然而，如果硫醇损失是衰老的原因，那么硫醇损失在组织衰老中的作用将得到加强。衰老生物学中的一个主要问题是区分原因和结果。细菌培养可以为这种探究提供一个相对简单的模型。
