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基于干细胞的 2019 冠状病毒病治疗。

Stem Cell-Based Therapy for Coronavirus Disease 2019.

机构信息

Department of Cell Biology, School of Life Sciences, Shanghai University, Shanghai, PR China.

出版信息

Stem Cells Dev. 2020 Jun 1;29(11):679-681. doi: 10.1089/scd.2020.0071. Epub 2020 Apr 17.

DOI:10.1089/scd.2020.0071
PMID:32292113
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7247051/
Abstract

The novel coronavirus disease 2019 (COVID-19) has grown to be a global public-health emergency since patients were first detected in Wuhan, China, in December 2019. As of April 9, 2020, the novel coronavirus (named as SARS-CoV-2 by the International Committee on Taxonomy of Viruses on February 11) has infected 83,251 and 1,484,811 patients in China and the world, respectively. However, we have neither confirmed effective antiviral medications nor vaccines available to deal with this emergency. In this commentary, we offer an alternative promising therapy for COVID-19, that is, mesenchymal stem cell transplantation.

摘要

2019 年新型冠状病毒病(COVID-19)自 2019 年 12 月在中国武汉首次发现患者以来,已成为全球公共卫生紧急事件。截至 2020 年 4 月 9 日,新型冠状病毒(国际病毒分类委员会于 2 月 11 日命名为 SARS-CoV-2)已分别在中国和世界范围内感染了 83251 和 1484811 人。然而,我们既没有确认有效的抗病毒药物,也没有可用的疫苗来应对这一紧急情况。在这篇评论中,我们为 COVID-19 提供了一种有前途的替代治疗方法,即间充质干细胞移植。

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Transplantation of ACE2 Mesenchymal Stem Cells Improves the Outcome of Patients with COVID-19 Pneumonia.血管紧张素转换酶2间充质干细胞移植改善新型冠状病毒肺炎患者的预后。
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A survey of 434 clinical trials about coronavirus disease 2019 in China.一项关于中国2019年冠状病毒病的434项临床试验的调查。
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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor.严重急性呼吸综合征冠状病毒 2 型(SARS-CoV-2)进入细胞依赖于 ACE2 和 TMPRSS2,可被一种临床验证的蛋白酶抑制剂所阻断。
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Epidemiologic Features and Clinical Course of Patients Infected With SARS-CoV-2 in Singapore.新加坡 2019 年新型冠状病毒肺炎患者的流行病学特征和临床病程
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Clinical Characteristics of Coronavirus Disease 2019 in China.《中国 2019 年冠状病毒病临床特征》
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