Edlich R F, Rodeheaver G T, Thacker J G, Winn H R, Edgerton M T
Clin Plast Surg. 1977 Apr;4(2):191-8.
The fate of a surgical wound is held in a delicate balance between the host's resistance to infection and the causal factors of infection. Considerable insight into this relationship between the host and pathogen can be gained from the results of quantitative bacteriologic measurements. Newer rapid slide techniques have been developed which provide the surgeon with this information within 20 minutes. In most soft tissue injuries, the wound bacterial count gives an accurate prediction of subsequent infection. Wounds combining greater than 10(5) bacteria per gram of tissue are destined to develop infection. When the bacterial count is below that level, the wounds will usually heal per primam without infection. This large number of bacteria required to elicit infection reflects the remarkable ability of soft tissues to resist infection. This state of high resistance to infection can be reduced by several factors which include circulatory embarrassment, tissue injury, dead space, and the presence of foreign bodies (dirt, sutures, drains, etc.). When treating soft tissue injuries, the surgeon must employ specific therapeutic modalities that allow the wound to heal per primam without infection. On the basis of experimental studies supported by clinical experience, the following treatment protocol for soft tissue injuries is recommended. Using strict aseptic technique, the wound must be first anesthetized with 1 per cent Xylocaine to permit painless sound cleansing. All wounds should be subjected to high pressure syringe irrigation to remove bacteria, foreign bodies, and blood clots. When necessary, debridement of all devitalized tissue should be performed with a stainless steel scalpel. Many wounds caused by sharp wounding agents contain no foreign bodies and few bacteria and exhibit considerable resistance to infection. In these wounds, primary closure can be initiated after irrigation without the development of infection. Wounds resulting from impact forces have a diminished resistance to infection and are susceptible to infection by low level of bacterial contamination. Immediate antibiotic treatment of patients with impact injuries subjected to meticulous debridement and cleansing will permit a safe primary closure. In wounds contacted by pus or feces, open wound management followed by delayed primary closure is usually indicated. Antimicrobial prophylaxis is also recommended for patients with such wounds. Ideal postoperative care of all traumatic wounds includes a surgical dressing and immobilization and elevation of the site of injury.
手术伤口的转归取决于宿主抗感染能力与感染致病因素之间的微妙平衡。通过定量细菌学测量结果,可以深入了解宿主与病原体之间的这种关系。现已开发出更新的快速玻片技术,可在20分钟内为外科医生提供此类信息。在大多数软组织损伤中,伤口细菌计数能准确预测后续感染情况。每克组织中细菌数量超过10⁵的伤口注定会发生感染。当细菌计数低于该水平时,伤口通常会一期愈合且不发生感染。引发感染所需的大量细菌反映了软组织卓越的抗感染能力。这种高度抗感染状态可因多种因素而降低,这些因素包括循环障碍、组织损伤、死腔以及异物(污垢、缝线、引流管等)的存在。在治疗软组织损伤时,外科医生必须采用特定的治疗方法,使伤口一期愈合且不发生感染。基于临床经验支持的实验研究,推荐以下软组织损伤治疗方案。采用严格的无菌技术,首先必须用1%的利多卡因对伤口进行麻醉,以便进行无痛的彻底清创。所有伤口都应进行高压注射器冲洗,以清除细菌、异物和血凝块。必要时,应用不锈钢手术刀对所有失活组织进行清创。许多由锐器造成的伤口不含异物且细菌很少,对感染具有相当的抵抗力。在这些伤口中,冲洗后可进行一期缝合而不会发生感染。由撞击力导致的伤口抗感染能力减弱,即使细菌污染水平较低也易发生感染。对接受了细致清创和清洗的撞击伤患者立即进行抗生素治疗,可实现安全的一期缝合。对于接触过脓液或粪便的伤口,通常应采用开放伤口处理,随后进行延迟一期缝合。对于此类伤口的患者,也建议进行抗菌预防。所有创伤伤口理想的术后护理包括手术敷料以及对受伤部位进行固定和抬高。