过敏及相关慢性炎症性气道疾病中的气道上皮动力学
Airway Epithelial Dynamics in Allergy and Related Chronic Inflammatory Airway Diseases.
作者信息
Laulajainen-Hongisto Anu, Toppila-Salmi Sanna Katriina, Luukkainen Annika, Kern Robert
机构信息
Department of Otorhinolaryngology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Laboratory of Cellular and Molecular Immunology, Institute of Microbiology of the Czech Academy of Sciences, Prague, Czechia.
出版信息
Front Cell Dev Biol. 2020 Mar 27;8:204. doi: 10.3389/fcell.2020.00204. eCollection 2020.
Allergic rhinitis, chronic rhinosinusitis, and asthma are highly prevalent, multifactorial chronic airway diseases. Several environmental and genetic factors affect airway epithelial dynamics leading to activation of inflammatory mechanisms in the airways. This review links environmental factors to host epithelial immunity in airway diseases. Understanding altered homeostasis of the airway epithelium might provide important targets for diagnostics and therapy of chronic airway diseases.
变应性鼻炎、慢性鼻-鼻窦炎和哮喘是高度流行的多因素慢性气道疾病。多种环境和遗传因素影响气道上皮动力学，导致气道炎症机制激活。本综述将环境因素与气道疾病中的宿主上皮免疫联系起来。了解气道上皮内稳态的改变可能为慢性气道疾病的诊断和治疗提供重要靶点。
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