Atri Deepak, Siddiqi Hasan K, Lang Joshua P, Nauffal Victor, Morrow David A, Bohula Erin A
Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
JACC Basic Transl Sci. 2020 Apr 10;5(5):518-536. doi: 10.1016/j.jacbts.2020.04.002. eCollection 2020 May.
Coronavirus disease-2019 (COVID-19), a contagious disease caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), has reached pandemic status. As it spreads across the world, it has overwhelmed health care systems, strangled the global economy, and led to a devastating loss of life. Widespread efforts from regulators, clinicians, and scientists are driving a rapid expansion of knowledge of the SARS-CoV-2 virus and COVID-19. The authors review the most current data, with a focus on the basic understanding of the mechanism(s) of disease and translation to the clinical syndrome and potential therapeutics. The authors discuss the basic virology, epidemiology, clinical manifestation, multiorgan consequences, and outcomes. With a focus on cardiovascular complications, they propose several mechanisms of injury. The virology and potential mechanism of injury form the basis for a discussion of potential disease-modifying therapies.
2019冠状病毒病（COVID-19）是一种由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起的传染病，已达到大流行状态。随着它在全球范围内传播，它使医疗系统不堪重负，扼杀了全球经济，并导致了毁灭性的生命损失。监管机构、临床医生和科学家的广泛努力正在推动对SARS-CoV-2病毒和COVID-19的认识迅速扩展。作者回顾了最新数据，重点是对疾病机制的基本理解以及向临床综合征和潜在治疗方法的转化。作者讨论了基本病毒学、流行病学、临床表现、多器官后果和结局。他们重点关注心血管并发症，提出了几种损伤机制。病毒学和潜在损伤机制构成了对潜在疾病改善疗法讨论的基础。
