Hospital Regional Universitario de Málaga, Servicio de Oftalmología, Spain.
Department of Doctoral Studies, Royal Liverpool University Hospital, UK; Riga Stradins University, Riga, Latvia.
Rom J Ophthalmol. 2020 Jan-Mar;64(1):62-65.
A 54-year-old patient presented with a large, fleshy conjunctival lesion in the right eye that had been previously surgically removed in another centre. Diagnosis of Conjunctival intraepithelial neoplasia (CIN) was confirmed by conjunctival impression cytology. The tumor was treated with topical IFN-α-2β (1,000,000 IU/ (ml) adjuvant to surgery for chemoreduction purposes. One month after treatment, the lesion showed almost complete involution, therefore the treatment was continued up to 6 months, and the lesion showed full regression. The patient is currently under periodical follow-up by conjunctival impression cytology. We consider that topical IFN-α-2β can be used in CIN for chemoreduction and/ or curative purposes. We believe that conjunctival impression cytology is a useful and non-invasive method for diagnosis and follow-up in this condition.
一位 54 岁患者右眼出现一个大而肉质的结膜病变，该病变先前已在另一家中心通过手术切除。结膜印片细胞学检查证实为结膜上皮内瘤变（CIN）。肿瘤通过局部应用 IFN-α-2β（100 万 IU/（ml））进行治疗，辅助手术进行化疗减瘤。治疗 1 个月后，病变几乎完全消退，因此继续治疗 6 个月，病变完全消退。目前患者定期接受结膜印片细胞学检查随访。我们认为，局部应用 IFN-α-2β 可用于 CIN 的化疗减瘤和/或治疗目的。我们认为结膜印片细胞学检查是诊断和随访这种疾病的一种有用且非侵入性的方法。
