Johansson Lindgren Jessica, Esbjörnsson Magnus, Tüzün Erdem, van Westen Danielle, Baureder REgina, Sahin Gürdal
ST-läkare i internmedicin, Närsjukvårdskliniken, Hässleholms sjukhus.
överläkare i neurologi och internmedicin, Närsjukvårdskliniken, Hässleholms sjukhus.
Lakartidningen. 2020 Apr 8;117:19200.
Anti-LGI-1 encephalitis is a type of autoimmune encephalopathy, where antibodies react against the cell surface protein leucine-rich glioma inactivated protein 1 (LGI-1). It presents with a subacute confusion, changes in behaviour, short-term memory deficits and seizures. A piloerectile semiology is common, which has been described as reflecting insular ictal activity. Patients may have temporal lobe abnormalities on brain MRI and EEG. More than half of the patients with limbic encephalitis associated with anti-LGI1 antibodies have hyponatremia. The diagnosis of anti-LGI-1 encephalitis can be made by the detection of antibodies against LGI-1 in serum and/or cerebrospinal fluid. Prompt diagnosis and treatment are important to avoid long-term disability. This case report describes a man with episodes of goose bumps and mild confusion caused by anti-LGI-1 encephalitis.
抗LGI-1脑炎是一种自身免疫性脑病，其中抗体与细胞表面蛋白富含亮氨酸的胶质瘤失活蛋白1（LGI-1）发生反应。其表现为亚急性意识模糊、行为改变、短期记忆缺陷和癫痫发作。竖毛发作症状很常见，被描述为反映岛叶发作活动。患者脑部MRI和脑电图可能出现颞叶异常。超过一半的抗LGI1抗体相关边缘性脑炎患者有低钠血症。抗LGI-1脑炎的诊断可通过检测血清和/或脑脊液中抗LGI-1抗体来进行。及时诊断和治疗对于避免长期残疾很重要。本病例报告描述了一名因抗LGI-1脑炎出现鸡皮疙瘩发作和轻度意识模糊的男性。
