抗 LGI1 抗体介导的自身免疫性脑炎的神经心理学谱。
The neuropsychological spectrum of anti-LGI1 antibody mediated autoimmune encephalitis.
机构信息
Department of Neurosciences, Faculty of Medicine, Nursing and Health Sciences, Central Clinical School, Monash University, Melbourne, VIC, Australia; Department of Neurology, Alfred Health, Melbourne, VIC, Australia.
Department of Neurosciences, Faculty of Medicine, Nursing and Health Sciences, Central Clinical School, Monash University, Melbourne, VIC, Australia; Department of Neurology, Alfred Health, Melbourne, VIC, Australia; Department of Neurology, Melbourne Health, Parkville, VIC, Australia; Department of Medicine, The Royal Melbourne Hospital, Parkville, VIC, Australia.
出版信息
J Neuroimmunol. 2020 Aug 15;345:577271. doi: 10.1016/j.jneuroim.2020.577271. Epub 2020 May 22.
Anti-Leucine Glioma Inactivated 1 (LGI-1) autoimmune encephalitis (AE) is a rare neuroinflammatory brain condition. Individuals afflicted with this condition can present with cognitive and psychological manifestations that can impact the individual's quality of life, day to day functioning, independence, return to work and interpersonal relationships. Our knowledge of the cognitive profiles and disease associated psychopathology is severely lacking. This review provides a comprehensive summary of the currently available literature, conceptualising our current understanding of the neuropsychological manifestations of anti LGI-1 AE and summarises methodological limitations of the current research to inform and improve future investigations. Key Terms: Autoimmune Diseases; Neuroimmunology; Autoimmune Encephalitis, Limbic Encephalitis; Anti-LGI1 Encephalitis, LGI1; Neuropsychology, Cognitive Assessment.
抗亮氨酸胶质瘤失活 1 型 (LGI-1) 自身免疫性脑炎 (AE) 是一种罕见的神经炎症性脑疾病。患有这种疾病的个体可能会出现认知和心理表现，从而影响个体的生活质量、日常功能、独立性、重返工作岗位和人际关系。我们对认知特征和与疾病相关的精神病理学的了解严重不足。这篇综述提供了目前文献的全面总结，概念化了我们对抗 LGI-1AE 的神经心理表现的现有理解，并总结了当前研究的方法学局限性，以为未来的研究提供信息和改进。 关键词：自身免疫性疾病；神经免疫学；自身免疫性脑炎，边缘性脑炎；抗 LGI1 脑炎，LGI1；神经心理学，认知评估。
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