Department of Medical Laboratory Sciences, Jordan University of Science and Technology, Irbid, Jordan.
Andrologia. 2020 Jul;52(6):e13592. doi: 10.1111/and.13592. Epub 2020 Apr 15.
Statins are lipid-lowering medications widely used to reduce the risk of cardiovascular diseases. Biochemically, they act by decreasing synthesis of cholesterol via inhibiting 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase. Since 1992, various research studies have investigated the effect of statins on semen quality characteristics; however, to date, there is no collective summary to such effect. Here, we have systematically discussed and abridged all research studies published in Scopus, PubMed and Web of Science databases that are directly linking statin to semen fertility characteristics using the keywords "statin" versus "sperm" and "semen". In summary, considering the animal studies, statins, in general, were found to ameliorate semen quality characteristics in reproductive detrimental conditions, while, in human males or in in vivo systems with normal reproductive conditions, in general, statins showed negative to blunt effects against semen quality characteristics, mainly sperm motility. However, further research studies, in particular human studies, in this specific research setting is still needed to approve these effects.
他汀类药物是广泛用于降低心血管疾病风险的降脂药物。从生化角度来看，它们通过抑制 3-羟基-3-甲基戊二酰基辅酶 A 还原酶来减少胆固醇的合成。自 1992 年以来，各种研究都调查了他汀类药物对精液质量特征的影响；然而，迄今为止，尚无对此类影响的综合总结。在这里，我们使用“他汀类药物”与“精子”和“精液”这两个关键词，系统地讨论并简化了发表在 Scopus、PubMed 和 Web of Science 数据库中所有直接将他汀类药物与精液生育特征联系起来的研究。总的来说，考虑到动物研究，他汀类药物通常被发现可以改善生殖不良条件下的精液质量特征，而在人类男性或正常生殖条件下的体内系统中，他汀类药物通常对精液质量特征表现出负面或钝性作用，主要是精子运动能力。然而，在这个特定的研究领域，仍需要进一步的研究，特别是人类研究，以证实这些影响。
