Robbie M J, Scurry J P, Stevenson P
Monash Medical Centre, Clayton, Australia.
Drug Intell Clin Pharm. 1988 Oct;22(10):783-4. doi: 10.1177/106002808802201010.
Skin rash, fever, and eosinophilia developed in a previously healthy 35-year-old woman three weeks after starting carbamazepine. Fulminant respiratory and renal failure ensued. Autopsy showed pneumonitis, nephritis, serositis, pancreatitis, hepatitis, and carditis, characterized by an infiltrate of eosinophils and lymphocytes. The severity, duration, and extensive organ involvement of the reaction make this case unique.
一名35岁既往健康的女性在开始服用卡马西平三周后出现皮疹、发热和嗜酸性粒细胞增多。随后出现暴发性呼吸和肾衰竭。尸检显示肺炎、肾炎、浆膜炎、胰腺炎、肝炎和心肌炎，其特征为嗜酸性粒细胞和淋巴细胞浸润。该反应的严重程度、持续时间及广泛的器官受累使此病例独具特色。
