"C.I. Parhon" Institute of Endocrinology, Bucharest, Romania.
Department of Endocrinology, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
Endokrynol Pol. 2020;71(3):235-239. doi: 10.5603/EP.a2020.0020. Epub 2020 Apr 15.
In Romania, there is no acromegaly national register and there are no nationwide data available. However, some studies have reported the control rates in the country's main referral centres. Our aim was to assess the overall control rate in our tertiary referral centre. Also, we assessed the control rate in the last three years, and we compared the results with our previous reports.
We reviewed the charts of 186 patients with acromegaly assessed in our department between January 1st, 2012 and May 31st, 2019. We also compared the control rates for patients treated between April 1st, 2016 and May 31st, 2019 with historical controls (assessed between January 1st, 2012 and March 31st, 2016).
Primary analysis: There were 19 untreated and 167 treated patients, mean age 52.46 years, surgery being the most commonly used treatment. The surgical cure rate was 14.8%, and disease control with medical treatment was 35.3%. Secondary analysis: In the first group there were 45 patients, surgery also being the most commonly used treatment. The surgical cure rate was 26.9%, and disease control was 30.4%. In the second group (historical controls) there were 42 patients, surgery being the most commonly used treatment. The surgical cure rate was 9.7%, and disease control with medical treatment was 15.4%. Random GH and IGF-1 after surgery were lower in the first group (p < 0.05) CONCLUSIONS: Changes in the Romanian protocol and highly specialised pituitary centres has improved the cure rate and disease control in patients with acromegaly.
在罗马尼亚，没有肢端肥大症国家登记处，也没有全国范围的数据。然而，一些研究报告了该国主要转诊中心的控制率。我们的目的是评估我们的三级转诊中心的总体控制率。此外，我们评估了过去三年的控制率，并将结果与我们之前的报告进行了比较。
我们回顾了 2012 年 1 月 1 日至 2019 年 5 月 31 日期间在我们部门评估的 186 例肢端肥大症患者的图表。我们还比较了 2016 年 4 月 1 日至 2019 年 5 月 31 日期间治疗的患者的控制率与历史对照（评估时间为 2012 年 1 月 1 日至 2016 年 3 月 31 日）。
主要分析：有 19 例未治疗和 167 例治疗患者，平均年龄 52.46 岁，手术是最常用的治疗方法。手术治愈率为 14.8%，药物治疗控制率为 35.3%。次要分析：在第一组中，有 45 例患者，手术也是最常用的治疗方法。手术治愈率为 26.9%，疾病控制率为 30.4%。在第二组（历史对照）中，有 42 例患者，手术是最常用的治疗方法。手术治愈率为 9.7%，药物治疗控制率为 15.4%。手术后随机 GH 和 IGF-1 在第一组中较低（p<0.05）。
罗马尼亚方案的改变和高度专业化的垂体中心改善了肢端肥大症患者的治愈率和疾病控制率。
