Department of Family Medicine, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, Republic of Korea.
Department of Neurology, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Republic of Korea.
Mov Disord. 2020 Jul;35(7):1263-1267. doi: 10.1002/mds.28055. Epub 2020 Apr 15.
If mild parkinsonian signs can be a marker for Parkinson's disease (PD) development, an impaired Timed Up and Go test (TUG) should also be a marker for prodromal PD.
To investigate whether the Timed Up and Go test is associated with PD.
We included 1,196,614 participants at 66 years of age who underwent the National Screening Program for Transitional Ages for Koreans between 2009 and 2014. Timed Up and Go test times were classified into <10 and ≥10 seconds. Incidence of PD was defined using claims data.
During the median follow-up period of 3.5 years, participants with slow Timed Up and Go test time had significantly increased risk of developing PD compared with those with normal Timed Up and Go test time (adjusted hazard ratio: 1.28; 95% confidence interval: 1.20-1.37). Furthermore, participants with an abnormal Timed Up and Go test result, defined as ≥20 seconds, had a significantly increased risk of PD compared with those with a normal Timed Up and Go test result (adjusted hazard ratio: 2.18; 95% confidence interval: 1.63-2.92).
An indicator of subtle motor deficits, the Timed Up and Go test could be a prodromal marker for the risk of PD development. © 2020 International Parkinson and Movement Disorder Society.
如果轻微的帕金森症状可以作为帕金森病（PD）发展的标志物，那么动作计时测试（TUG）异常也应该是前驱期 PD 的标志物。
探讨 TUG 与 PD 的相关性。
我们纳入了 2009 年至 2014 年期间参加韩国国民筛查计划的 66 岁以上的 1,196,614 名参与者。TUG 测试时间分为<10 秒和≥10 秒。使用索赔数据定义 PD 的发生率。
在中位随访 3.5 年期间，与 TUG 测试时间正常的参与者相比，TUG 测试时间较慢的参与者发生 PD 的风险显著增加（校正后的危险比：1.28；95%置信区间：1.20-1.37）。此外，与 TUG 测试结果正常的参与者相比，TUG 测试结果异常（定义为≥20 秒）的参与者发生 PD 的风险显著增加（校正后的危险比：2.18；95%置信区间：1.63-2.92）。
作为细微运动缺陷的指标，TUG 可能是 PD 发展风险的前驱期标志物。 © 2020 国际帕金森病和运动障碍学会。
