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简短的、每周一次的磁刺激肌肉疗法可改善老年人的活动能力和去脂体重:东南亚社区案例研究。

Brief, weekly magnetic muscle therapy improves mobility and lean body mass in older adults: a Southeast Asia community case study.

机构信息

QuantumTx, Alexandra Hospital, Block 29 Level 1 Centre for Innovation in Healthcare, Co-Working Space, Singapore.

Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

出版信息

Aging (Albany NY). 2023 Mar 19;15(6):1768-1790. doi: 10.18632/aging.204597.

Abstract

Brief (10 min) weekly exposure to low energy pulsed electromagnetic fields (PEMFs) has been shown to improve human muscle mitochondrial bioenergetics and attenuate systemic lipotoxicity following anterior cruciate ligament surgical reconstruction. Here we present data generated from 101 participants, 62% female, aged 38-91 years, recruited from the QuantumTx Demo Centre in Singapore, wherein 87% of participants ( = 88) presented with pre-existing mobility dysfunction and 13% ( = 13) were healthy volunteers. Participants were recruited if: (i) not pregnant; (ii) above 35 years of age and; (iii) without surgical implants. All participants completed mobility testing, pre- and post- PEMF intervention for 12 weeks, whereas bioelectrical impedance analysis was conducted in a subgroup of 42 and 33 participants at weeks 4 and 8, respectively. Weekly PEMF exposure was associated with significant improvements in mobility (Timed Up and Go, 5 times Sit-to-Stand, and 4m Normal Gait Speed) and body composition (increased skeletal muscle mass and reduced total and visceral fat mass), particularly in the older participants. Perception of pain was also significantly reduced. PEMF therapy may provide a manner to counteract age-associated mobility and metabolic disruptions and merits future investigation in randomized controlled trials to elucidate its clinical benefits in the frail and older adult populations.

摘要

简短(10 分钟)每周接触低能量脉冲电磁场(PEMF)已被证明可改善人类肌肉线粒体生物能学,并减轻前交叉韧带手术后的全身脂肪毒性。在这里,我们提供了来自新加坡 QuantumTx 演示中心的 101 名参与者的数据,其中 62%为女性,年龄在 38-91 岁之间,其中 87%的参与者(=88)存在预先存在的活动障碍,13%(=13)为健康志愿者。如果符合以下条件,参与者即可被招募:(i)未怀孕;(ii)年龄超过 35 岁;(iii)没有手术植入物。所有参与者均完成了移动性测试,在 12 周内接受了 PEMF 干预前后的测试,而生物电阻抗分析则分别在 42 名和 33 名参与者中在第 4 周和第 8 周进行。每周 PEMF 暴露与移动性(起身时间和坐下,5 次站立和 4 米正常步行速度)和身体成分(增加骨骼肌质量和减少总脂肪和内脏脂肪量)的显著改善有关,尤其是在年龄较大的参与者中。疼痛的感知也显著降低。PEMF 治疗可能提供一种对抗与年龄相关的运动和代谢障碍的方法,值得在随机对照试验中进一步研究,以阐明其在虚弱和老年人群中的临床益处。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c329/10085623/ba95745f743e/aging-15-204597-g001.jpg

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