Department of Infectious Disease and Clinical, Microbiology, İstanbul Faculty of Medicine, İstanbul University, İstanbul, Turkey
Department of Infectious Disease, Faculty of Medicine, Hacettepe University, Ankara, Turkey
Turk J Med Sci. 2020 Apr 21;50(SI-1):611-619. doi: 10.3906/sag-2004-145.
Currently, there is not any specific effective antiviral treatment for COVID-19. Although most of the COVID-19 patients have mild or moderate courses, up to 5%–10% can have severe, potentially life threatening course, there is an urgent need for effective drugs. Optimized supportive care remains the mainstay of therapy. There have been more than 300 clinical trials going on, various antiviral and immunomodulating agents are in various stages of evaluation for COVID-19 in those trials and some of them will be published in the next couple of months. Despite the urgent need to find an effective antiviral treatment for COVID-19 through randomized controlled studies, certain agents are being used all over the world based on either in-vitro or extrapolated evidence or observational studies. The most frequently used agents both in Turkey and all over the world including chloroquine, hydroxychloroquine, lopinavir/ritonavir, favipiravir and remdesivir will be reviewed here .Nitazoxanide and ivermectin were also included in this review as they have recently been reported to have an activity against SARS-CoV-2 in vitro and are licensed for the treatment of some other human infections.
目前，针对 COVID-19 没有任何特效的抗病毒治疗方法。尽管大多数 COVID-19 患者的病程较轻或中度，但高达 5%-10%的患者可能会出现严重、甚至危及生命的病程，因此急需有效的药物。优化的支持性治疗仍然是治疗的主要方法。目前已有 300 多项临床试验正在进行，在这些试验中，各种抗病毒和免疫调节剂都处于评估 COVID-19 的不同阶段，其中一些将在未来几个月内公布。尽管通过随机对照研究迫切需要找到针对 COVID-19 的有效抗病毒治疗方法，但某些药物仍在全球范围内使用，其依据是体外或推断证据或观察性研究。本综述将回顾在土耳其和世界各地最常使用的药物，包括氯喹、羟氯喹、洛匹那韦/利托那韦、法匹拉韦和瑞德西韦。硝唑尼特和伊维菌素也被包括在本综述中，因为它们最近被报道在体外对 SARS-CoV-2 具有活性，并且被批准用于治疗其他一些人类感染。
