在小鼠热板试验中，脑室内注射法氯芬可拮抗巴氯芬的抗伤害感受活性。 - Suppr | 超能文献

Intracerebroventricular phaclofen antagonizes baclofen antinociceptive activity in hot plate test with mice.

作者信息

Giuliani S, Evangelista S, Borsini F, Meli A

机构信息

Pharmacology Department, Research Laboratories A. Menarini Pharmaceuticals, Florence, Italy.

出版信息

Eur J Pharmacol. 1988 Sep 13;154(2):225-6. doi: 10.1016/0014-2999(88)90105-7.

DOI:10.1016/0014-2999(88)90105-7

Abstract

摘要

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Intracerebroventricular phaclofen antagonizes baclofen antinociceptive activity in hot plate test with mice.在小鼠热板试验中，脑室内注射法氯芬可拮抗巴氯芬的抗伤害感受活性。

Eur J Pharmacol. 1988 Sep 13;154(2):225-6. doi: 10.1016/0014-2999(88)90105-7.

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Phaclofen antagonizes the antinociceptive but not the sedative effects of (-)-baclofen.法氯芬可拮抗（-）-巴氯芬的抗伤害感受作用，但不拮抗其镇静作用。

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Antagonism of baclofen-induced antinociception by intrathecal administration of phaclofen or 2-hydroxy-saclofen, but not delta-aminovaleric acid in the rat.

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The effect of intracerebroventricular administration of baclofen on food intake in rats.脑室内注射巴氯芬对大鼠食物摄入量的影响。

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Phaclofen-sensitive GABA-B receptors do not mediate excitatory effects of baclofen on gastric secretion.对酞氯苯氧胺敏感的γ-氨基丁酸B型受体不介导巴氯芬对胃酸分泌的兴奋作用。

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Baclofen is antinociceptive in the spinal intrathecal space of animals.

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Antinociception produced by systemic R(+)-baclofen hydrochloride is attenuated by CGP 35348 administered to the spinal cord or ventromedial medulla of rats.全身性给予盐酸R(+)-巴氯芬产生的抗伤害感受作用，会被给予大鼠脊髓或延髓腹内侧的CGP 35348减弱。

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The analgesic action of baclofen [beta-(4-chlorophenyl)-gamma-aminobutyric acid].巴氯芬[β-(4-氯苯基)-γ-氨基丁酸]的镇痛作用。

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Involvement of GABA systems in feedback regulation of glutamate-and GABA-mediated synaptic potentials in rat neostriatum.γ-氨基丁酸（GABA）系统参与大鼠新纹状体中谷氨酸和GABA介导的突触电位的反馈调节。

J Physiol. 1991;440:581-99. doi: 10.1113/jphysiol.1991.sp018726.

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CGP 35348, a new GABAB antagonist, prevents antinociception and muscle-relaxant effect induced by baclofen.新型GABAB拮抗剂CGP 35348可预防巴氯芬诱导的抗伤害感受和肌肉松弛作用。

Br J Pharmacol. 1991 Jun;103(2):1303-8. doi: 10.1111/j.1476-5381.1991.tb09784.x.