Ciceri Fabio, Beretta Luigi, Scandroglio Anna Mara, Colombo Sergio, Landoni Giovanni, Ruggeri Annalisa, Peccatori Jacopo, D'Angelo Armando, De Cobelli Francesco, Rovere-Querini Patrizia, Tresoldi Moreno, Dagna Lorenzo, Zangrillo Alberto
Department of Hematology and Stem Cell Transplantation, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Vita-Salute San Raffaele University, Milan, Italy.
Crit Care Resusc. 2020 Apr 15;22(2):95-97. doi: 10.51893/2020.2.pov2.
We suggest the use of MicroCLOTS (microvascular COVID-19 lung vessels obstructive thromboinflammatory syndrome) as a new name for severe pulmonary coronavirus disease 2019 (COVID-19). We hypothesise that, in predisposed individuals, alveolar viral damage is followed by an inflammatory reaction and by microvascular pulmonary thrombosis. This progressive endothelial thromboinflammatory syndrome may also involve the microvascular bed of the brain and other vital organs, leading to multiple organ failure and death. Future steps in the understanding of the disease and in the identification of treatments may benefit from this definition and hypothesised sequence of events.
我们建议使用“微血管新冠肺血管阻塞性血栓炎症综合征（MicroCLOTS）”作为2019年重症冠状病毒病（COVID-19）的新名称。我们推测，在易感个体中，肺泡病毒损伤后会出现炎症反应和微血管肺血栓形成。这种进行性内皮血栓炎症综合征也可能累及脑和其他重要器官的微血管床，导致多器官功能衰竭和死亡。对该疾病的进一步认识以及治疗方法的确定可能会受益于这一定义以及所推测的事件顺序。
