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Clonal hematopoiesis of indeterminate potential associates with higher risk of thromboembolism in severe COVID-19.

作者信息

Bergonzi Gregorio Maria, Galimard Jacques-Emmanuel, Aletti Federico Mario, Angelillo Piera, Mastaglio Sara, Erbella Federico, Palumbo Diego, Calori Giliola, Querini Patrizia Rovere, Tresoldi Cristina, Fragasso Gabriele, De Cobelli Francesco, Assanelli Andrea Angelo, Ciceri Fabio, Della Porta Matteo G, Ruggeri Annalisa, Bernardi Massimo

机构信息

Vita-Salute San Raffaele University, Milan, Italy; Unit of Hematology and Bone Marrow Transplant, IRCCS San Raffaele Scientific Institute, Milan.

EBMT Paris Study Unit, Saint-Antoine Hospital, Paris.

出版信息

Haematologica. 2025 Sep 1;110(9):2214-2218. doi: 10.3324/haematol.2024.287128. Epub 2025 Mar 20.

DOI:10.3324/haematol.2024.287128
PMID:40109188
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12399948/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a50b/12399948/fbd9b106d59d/1102214.fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a50b/12399948/fbd9b106d59d/1102214.fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a50b/12399948/fbd9b106d59d/1102214.fig1.jpg

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本文引用的文献

1
JAK2-mutant clonal hematopoiesis is associated with venous thromboembolism.JAK2 突变性克隆性造血与静脉血栓栓塞相关。
Blood. 2024 Nov 14;144(20):2149-2154. doi: 10.1182/blood.2024024187.
2
Use of defibrotide in COVID-19 pneumonia: comparison of a phase II study and a matched real-world cohort control.COVID-19 肺炎中使用 defibrotide：一项 II 期研究与匹配的真实世界队列对照比较。
Haematologica. 2024 Oct 1;109(10):3261-3268. doi: 10.3324/haematol.2024.285345.
3
Common and rare variant associations with clonal haematopoiesis phenotypes.
常见和罕见变异与克隆性造血表型的关联。
Nature. 2022 Dec;612(7939):301-309. doi: 10.1038/s41586-022-05448-9. Epub 2022 Nov 30.
4
Clonal hematopoiesis is not significantly associated with COVID-19 disease severity.克隆性造血与新冠病毒疾病严重程度无显著关联。
Blood. 2022 Oct 6;140(14):1650-1655. doi: 10.1182/blood.2022015721.
5
The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms.世界卫生组织血液淋巴肿瘤分类第五版：髓系和组织细胞/树突状肿瘤。
Leukemia. 2022 Jul;36(7):1703-1719. doi: 10.1038/s41375-022-01613-1. Epub 2022 Jun 22.
6
Clonal hematopoiesis is associated with risk of severe Covid-19.克隆性造血与严重 COVID-19 风险相关。
Nat Commun. 2021 Oct 13;12(1):5975. doi: 10.1038/s41467-021-26138-6.
7
Clinical relevance of clonal hematopoiesis in persons aged ≥80 years.80 岁及以上人群中克隆性造血的临床意义。
Blood. 2021 Nov 25;138(21):2093-2105. doi: 10.1182/blood.2021011320.
8
Clonal hematopoiesis in patients with Covid-19 is stable and not linked to an aggravated clinical course.新冠病毒肺炎患者的克隆性造血是稳定的，且与病情加重无关。
Am J Hematol. 2021 Sep 1;96(9):E331-E333. doi: 10.1002/ajh.26251. Epub 2021 Jun 2.
9
Pathophysiology of COVID-19-associated acute respiratory distress syndrome: a multicentre prospective observational study.COVID-19 相关性急性呼吸窘迫综合征的病理生理学：一项多中心前瞻性观察研究。
Lancet Respir Med. 2020 Dec;8(12):1201-1208. doi: 10.1016/S2213-2600(20)30370-2. Epub 2020 Aug 27.
10
Early predictors of clinical outcomes of COVID-19 outbreak in Milan, Italy.意大利米兰新冠疫情临床结局的早期预测指标。
Clin Immunol. 2020 Aug;217:108509. doi: 10.1016/j.clim.2020.108509. Epub 2020 Jun 12.