Tan F R, Qiu Y L, Xu Z
Department of Respiratory Medicine, the Third People' Hospital of Changzhou, Jiangsu 213001, China.
Zhonghua Jie He He Hu Xi Za Zhi. 2020 Apr 12;43(4):337-339. doi: 10.3760/cma.j.cn112147-20200224-00167.
The case reports 2 cases of novel coronavirus pneumonia diagnosed by concurrent bronchoalveolar lavage in our hospital, 1 case had a history of epidemiology, clinical symptoms and high imaging suspicion, but repeated negative throat swabs. One patient was diagnosed 2019-nCoV. Before the patient was discharged, the clinical symptoms disappeared, the chest CT showed significant improvement, and the pharynx swab was twice negative, reaching the discharge standard.We detected the ORF 1ab gene, the N gene and the nucleic acid of the new coronavirus in the broncho-alveolar lavage fluid of 2 patients. The results showed that the positive rate of bronchoalveolar lavage for detection of new coronavirus nucleic acid was high, and bronchoalveolar lavage for suspected or confirmed new coronavirus pneumonia patients with negative detection of nucleic acid in pharynx swabs but still residual lung lesions was helpful for early diagnosis, treatment and prognosis.
该病例报告了我院通过同时进行支气管肺泡灌洗诊断的2例新型冠状病毒肺炎病例，1例有流行病学史、临床症状且影像学高度怀疑，但咽拭子多次阴性。1例患者确诊为2019 - nCoV。患者出院前，临床症状消失，胸部CT显示明显改善，咽拭子两次阴性，达到出院标准。我们在2例患者的支气管肺泡灌洗液中检测到新型冠状病毒的ORF 1ab基因、N基因及核酸。结果显示，支气管肺泡灌洗检测新型冠状病毒核酸的阳性率较高，对于咽拭子核酸检测阴性但仍有肺部病变残留的疑似或确诊新型冠状病毒肺炎患者，支气管肺泡灌洗有助于早期诊断、治疗及预后评估。
