使用7特斯拉“静音”零回波时间成像对接受或未接受艾地苯醌治疗的Leber遗传性视神经病变患者的视神经进行评估。

The Evaluation of Optic Nerves Using 7 Tesla "Silent" Zero Echo Time Imaging in Patients with Leber's Hereditary Optic Neuropathy with or without Idebenone Treatment.

作者信息

Grochowski Cezary, Symms Mark, Jonak Kamil, Krukow Paweł, Wood Tobias, Ljungberg Emil, Enseñat Joaquim, Nowomiejska Katarzyna, Rejdak Robert, Maciejewski Ryszard, Barker Gareth J

机构信息

Department of Anatomy, Medical University of Lublin, Lublin, 20-400 Lublin, Poland.

Department of Neurosurgery, Hospital Clínic de Barcelona, University of Barcelona, 08007 Barcelona, Spain.

出版信息

J Clin Med. 2020 Apr 13;9(4):1112. doi: 10.3390/jcm9041112.

DOI:10.3390/jcm9041112

PMID:32295018

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7230870/

Abstract

Magnetic Resonance Imaging (MRI) of the Optic Nerve is difficult due to the fine extended nature of the structure, strong local magnetic field distortions induced by anatomy, and large motion artefacts associated with eye movement. To address these problems we used a Zero Echo Time (ZTE) MRI sequence with an Adiabatic SPectral Inversion Recovery (ASPIR) fat suppression pulse which also imbues the images with Magnetisation Transfer contrast. We investigated an application of the sequence for imaging the optic nerve in subjects with Leber's hereditary optic neuropathy (LHON). Of particular note is the sequence's near-silent operation, which can enhance image quality of the optic nerve by reducing the occurrence of involuntary saccades induced during Magnetic Resonance (MR) scanning.

摘要

对视神经进行磁共振成像（MRI）具有挑战性，这是由于该结构纤细且延伸范围广、解剖结构引起强烈的局部磁场畸变以及与眼球运动相关的大量运动伪影。为了解决这些问题，我们使用了零回波时间（ZTE）MRI序列，并结合绝热频谱反转恢复（ASPIR）脂肪抑制脉冲，该脉冲还能使图像具有磁化传递对比。我们研究了该序列在莱伯遗传性视神经病变（LHON）患者视神经成像中的应用。特别值得注意的是该序列近乎静音的运行，这可以通过减少磁共振（MR）扫描期间诱发的不自主眼跳的发生来提高视神经的图像质量。