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[食饵性高胆固醇血症对食糜及肠流出血液脂质成分的影响]

[Effect of alimentary hypercholesterolemia on the lipid composition of the chyme and of the blood flowing from the intestines].

作者信息

Bogdarin Iu A, Kulakova S N, Badeĭnova E N

出版信息

Fiziol Zh SSSR Im I M Sechenova. 1988 Oct;74(10):1462-70.

PMID:3229526
Abstract

The wall of the rabbit small intestine was found to take part in regulation of the balance of general lipids, fatty and bile acids of arterio-venous blood both in intact animals and in those with hypercholesterolemia. Excessive amount of cholesterol in food reconstructs the lipid composition of enterocytes which loose important bile and fatty acids, accumulating nonequivalent intermediary products of lipid metabolism which affects the membrane permeability, readjusts the lipid exchange in enterocytes and their control over lipid complexes circulating in the blood.

摘要

研究发现,无论是在正常动物还是高胆固醇血症动物中,兔小肠壁都参与调节动静脉血中总脂质、脂肪酸和胆汁酸的平衡。食物中过量的胆固醇会重塑肠细胞的脂质组成,导致肠细胞失去重要的胆汁酸和脂肪酸,积累脂质代谢的不等价中间产物,这会影响膜通透性,重新调整肠细胞中的脂质交换及其对血液中循环脂质复合物的控制。

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