胡皮色林 A 和 B，两种来自 的具有独特骨架的大环生物碱
Huperserratines A and B, Two Macrocyclic Alkaloids with an Unusual Skeleton from .
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
出版信息
J Org Chem. 2020 May 15;85(10):6803-6807. doi: 10.1021/acs.joc.0c00623. Epub 2020 Apr 28.
Huperserratines A () and B (), two alkaloids with an unprecedented 5-aza-bicyclo[10.4.0]hexadecane skeleton and an oxime function, were isolated from . Their structures including absolute configurations were determined by extensive NMR spectroscopic and X-ray diffraction analysis. Compounds and were the first examples of macrocyclic alkaloids with an aza-12-membered ring. A plausible biogenetic pathway of these compounds was also proposed. Compound exhibited moderate anti-HIV-1 activity with an EC of 52.91 μg/mL and a therapy index greater than 3.78.
海罂粟碱 A()和 B()，两种具有前所未有的 5-氮杂双环[10.4.0]十六烷骨架和肟功能的生物碱，从海罂粟中分离得到。通过广泛的 NMR 光谱和 X 射线衍射分析确定了它们的结构包括绝对构型。化合物和是具有氮杂 12 元环的大环生物碱的第一个例子。还提出了这些化合物的可能生物合成途径。化合物对 HIV-1 的活性中等，EC 值为 52.91 μg/mL，治疗指数大于 3.78。
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