蛇足石杉中的石杉碱甲 - 戊，石松生物碱
Huperserines A-E, Lycopodium alkaloids from Huperzia serrata.
作者信息
Jiang Wei-Wei, Liu Fei, Gao Xiu, He Juan, Cheng Xiao, Peng Li-Yan, Wu Xing-De, Zhao Qin-Shi
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China; University of the Chinese Academy of Sciences, Beijing 100049, PR China.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China.
出版信息
Fitoterapia. 2014 Dec;99:72-7. doi: 10.1016/j.fitote.2014.09.005. Epub 2014 Sep 16.
A phytochemical study on Huperzia serrata led to the isolation of four new 5-deoxyfawcettimine-related Lycopodium alkaloids, huperserines A-D (1-4), and one new lycodine-type alkaloid, huperserine E (5). Their structures were elucidated based on spectroscopic data, including 1D and 2D NMR techniques. 5-Carbonyl or 5-hydroxyl group is a typical characteristic of lycopodine- and fawcettimine-type alkaloids. This is the first report of the 5-deoxyfawcettimine type Lycopodium alkaloids. In vitro acetylcholinesterase (AChE) inhibitory activity assay showed that huperserine E exhibited moderate anti-AChE activity with an IC₅₀ value of 6.71 μM.
对蛇足石杉的植物化学研究导致分离出四种新的与5-脱氧法西替明相关的石松生物碱，蛇足石杉碱A-D（1-4），以及一种新的石蒜碱型生物碱，蛇足石杉碱E（5）。基于光谱数据，包括一维和二维核磁共振技术，阐明了它们的结构。5-羰基或5-羟基是石蒜碱型和法西替明型生物碱的典型特征。这是5-脱氧法西替明型石松生物碱的首次报道。体外乙酰胆碱酯酶（AChE）抑制活性测定表明，蛇足石杉碱E表现出中等的抗AChE活性，IC₅₀值为6.71 μM。
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