Department of Neurosurgery, Faculty of Medicine 13149Yamagata University, Yamagata, Japan.
Acta Radiol. 2021 Feb;62(2):225-233. doi: 10.1177/0284185120917111. Epub 2020 Apr 15.
Arterial transit time correction by data acquisition with multiple post-labeling delays (PLDs) or relatively long PLDs is expected to obtain more accurate imaging in cases of the cerebrovascular steno-occlusive disease. However, there have so far been no reports describing the significance of arterial spin labeling (ASL) images at short PLDs regarding the evaluation of cerebral circulation in ischemic cerebrovascular disease.
To clarify the role of short-PLD ASL in cerebrovascular steno-occlusive disease.
Fifty-three patients with cerebrovascular steno-occlusive disease were included in this study. All patients underwent ASL magnetic resonance imaging and O-PET within two days of each modality. To compare the ASL findings with each parameter of PET, the right-to-left (R/L) ratio, defined as the right middle cerebral artery (MCA) value/left MCA value, was calculated.
There is a significant correlation between the ASL images at a short PLD and the ratio of cerebral blood flow and cerebral blood volume by O-PET, which may accurately reflect the cerebral perfusion pressure. A receiver operating characteristic curve analysis indicated that ASL images at PLD 1000 and 1500 ms were more accurate than at PLD 2000-3000 ms for the detection of a ≥10% change in the PET cerebral blood flow.
ASL images at shorter PLDs may be useful at least as a screening modality to detect the changes in the cerebral circulation in cerebrovascular steno-occlusive disease. We must evaluate ASL images at multiple PLDs while considering the arterial transit time of each case at present.
通过使用多个标记后延迟（PLD）或相对较长的 PLD 进行数据采集进行动脉渡越时间校正，预计在脑血管狭窄-闭塞性疾病的情况下可以获得更准确的成像。然而，迄今为止，还没有关于在缺血性脑血管病中评估脑循环时，短 PLD 动脉自旋标记（ASL）图像的意义的报道。
阐明短 PLD ASL 在脑血管狭窄-闭塞性疾病中的作用。
本研究纳入了 53 例脑血管狭窄-闭塞性疾病患者。所有患者均在两种模态的两天内接受了 ASL 磁共振成像和 O-PET。为了将 ASL 发现与 PET 的每个参数进行比较，计算了右到左（R/L）比值，定义为右侧大脑中动脉（MCA）值/左侧 MCA 值。
短 PLD 的 ASL 图像与 O-PET 的脑血流量和脑血容量比值之间存在显著相关性，这可能准确反映脑灌注压。受试者工作特征曲线分析表明，PLD 为 1000 和 1500 ms 的 ASL 图像比 PLD 为 2000-3000 ms 更准确地检测出 PET 脑血流变化≥10%。
至少作为一种筛查手段，短 PLD 的 ASL 图像可能有助于检测脑血管狭窄-闭塞性疾病中脑循环的变化。目前，我们必须在考虑每个病例的动脉渡越时间的情况下，评估多个 PLD 的 ASL 图像。
