按需自噬网络适应有限的脂质可用性。
On-demand autophagic network adaptations upon limited lipid availability.
机构信息
Institute of Pathobiochemistry, University Medical Center of the Johannes Gutenberg University Mainz , Mainz, Germany.
出版信息
Autophagy. 2020 Jul;16(7):1348-1350. doi: 10.1080/15548627.2020.1753926. Epub 2020 Apr 16.
Abstract
The synthesis of autophagic vesicles is strongly dependent on sufficient lipid supply. Recently, the RAB GTPase RAB18 was shown to affect autophagy by mediating fatty acid release from lipid droplets, which are lipid sources for autophagosome formation. The stable loss of RAB18 interfered with fatty acid release from the lipid reservoirs and provoked autophagy network adaptations aiming to maintain autophagic activity under lipid limiting conditions.
摘要
自噬小泡的合成强烈依赖于充足的脂质供应。最近，RAB GTPase RAB18 通过介导从脂质滴释放脂肪酸来影响自噬，脂质滴是自噬体形成的脂质来源。RAB18 的稳定缺失干扰了从脂质库中释放脂肪酸，并引发了自噬网络的适应性改变，旨在在脂质限制条件下维持自噬活性。
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