Older age at infection and nulliparity are associated with long-term non-progression in female sex workers infected with non-subtype B HIV-1.

BACKGROUND

: Studies have reported on HIV-infected, antiretroviral therapy (ART)-naïve individuals who show minimal disease progression despite prolonged infection. The characteristics of these long-term non-progressors (LTNPs) are not well-characterized in populations predominantly infected with non-subtype-B HIV-1.

METHODS

: Female sex workers in Mombasa, Kenya who acquired HIV-1 were studied to ascertain immunological disease progression. Long-term non-progression was defined as an ART-naïve duration of infection ≥7 years and a majority of CD4+ counts ≥600 cells/µL with a non-declining CD4+ trend. Correlates of long-term non-progression were determined using multivariable logistic regression.

RESULTS

: Between February 1993 and March 2014, 332 women acquired HIV-1. Of these, 77 (23%) had ≥7 years of follow-up and 13 (17%) were categorised as LTNPs. Factors associated with long-term non-progression included age >30 years at infection (aOR=9.41, 95% CI: 1.48–59.86, P=0.005) and nulliparity (aOR=20.19, 95% CI: 1.36–299.90, P=0.03). Each log10 increase in viral set point was associated with a lower likelihood of being a LTNP (aOR=0.31, 95% CI: 0.12–0.79, P=0.01).

CONCLUSION

: These findings suggest that age and parity may influence the likelihood of long-term non-progression through mechanisms that are not mediated by the effects of these variables on viral load. Future studies should seek to determine whether the associations presented are reproducible.