Kanki P J, Hamel D J, Sankalé J L, Hsieh C c, Thior I, Barin F, Woodcock S A, Guèye-Ndiaye A, Zhang E, Montano M, Siby T, Marlink R, NDoye I, Essex M E, MBoup S
Department of Immunology, Harvard School of Public Health, Boston, Massachusetts, USA.
J Infect Dis. 1999 Jan;179(1):68-73. doi: 10.1086/314557.
At least 10 different genetic human immunodeficiency virus type 1 (HIV-1) subtypes (A-J) are responsible for the AIDS pandemic. Much of the understanding of HIV-1 disease progression derives from studies in the developed world where HIV infection is almost exclusively subtype B. This has led many to question whether the properties and consequences of HIV-1 infection can be generalized across subtypes that afflict the majority of infected persons in the developing world. From 1985 to 1997, a prospective study of registered female sex workers in Senegal tracked the introduction and spread of HIV-1 subtypes A, C, D, and G. In clinical follow-up, the AIDS-free survival curves differed by HIV-1 subtype. Women infected with a non-A subtype were 8 times more likely to develop AIDS than were those infected with subtype A (hazard ratio=8.23; P=. 009), the predominant subtype in the study. These data suggest that HIV-1 subtypes may differ in rates of progression to AIDS.
至少10种不同的基因1型人类免疫缺陷病毒（HIV-1）亚型（A - J）导致了艾滋病的大流行。对HIV-1疾病进展的许多理解都来自发达国家的研究，在那里HIV感染几乎全是B亚型。这使得许多人质疑HIV-1感染的特性和后果是否能推广到影响发展中国家大多数感染者的其他亚型。1985年至1997年，对塞内加尔登记在册的女性性工作者进行的一项前瞻性研究追踪了HIV-1亚型A、C、D和G的传入与传播。在临床随访中，无艾滋病生存曲线因HIV-1亚型而异。感染非A亚型的女性患艾滋病的可能性是感染A亚型女性的8倍（风险比 = 8.23；P = 0.009），A亚型是该研究中的主要亚型。这些数据表明，HIV-1亚型在发展为艾滋病的速率上可能存在差异。
